Human CD42b/GPIb alpha (NP_000164) VersaClone cDNA

Catalog # Availability Size / Price Qty
RDC1834
Product Details
FAQs
Reviews

Human CD42b/GPIb alpha (NP_000164) VersaClone cDNA Summary

Platelet glycoprotein Ib alpha chain (GPIb alpha), also known as CD42b alpha, is a 145 kDa type I transmembrane protein that is a member of the leucine-rich repeat (LRR) family of ligand binding proteins. It is expressed by platelets as the ligand-binding subunit of the platelet GPIb-IX-V complex. Human GPIb alpha contains a 16 amino acid (aa) signal sequence, a 489 aa extracellular domain (ECD), a 21-aa transmembrane domain, and a 100 aa cytoplasmic region. The ECD contains 8 LRRs, with numbers 2, 3 and 4 having been demonstrated to regulate shear-dependent adhesion to von Willebrand factor (vWF). The LRRs are followed by a thrombin-binding anionic region that includes three sulfated tyrosines, a sialomucin domain with N- and O-linked carbohydrates, and two cysteines near the membrane that allow dimerization with GP1b alpha/beta. Four human isoforms with 1 to 4 repeats of aa 398-411 within the sialomucin domain of mature GPIb alpha are known to exist but have unknown significance. The ECD of human GPIb alpha shares 48 - 51% aa identity with mouse, rat, bovine and canine GPIb alpha. The metalloproteinase TACE/ADAM17 constitutively and inducibly cleaves GPIb alpha, between Gly480 and Val481. This releases a soluble form called glycocalicin that circulates at ~2 micrograms/mL. GPIb alpha binding to ligands such as thrombin, kininogen, and coagulation factors XI and XII helps to initiate platelet activation and coordinate the coagulation cascade. Binding of GPIb alpha to vWF or thrombospondin in the plasma or matrix, vWF or P-selectin on endothelial cells, or the integrin alphaM beta2 (MAC-1) on myeloid cells, controls response to vascular injury. Bernard-Soulier syndrome and platelet-type von Willebrand disease are platelet function disorders that can be caused by mutations in GPIb alpha.

Specifications

Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

Product Datasheets

Background: CD42b/GPIb alpha

Long Name
Glycoprotein lb [Platelet] alpha
Entrez Gene IDs
2811 (Human); 14723 (Mouse)
Alternate Names
Antigen CD42b-alpha; BP1BA; BSS; CD42b antigen; CD42b; CD42b-alpha; glycoprotein Ib (platelet), alpha polypeptide; Glycoprotein Ibalpha; GP1B; GP1BA; GPIb alpha; GP-Ib alpha; GPIbA; GPIb-alpha; MGC34595; platelet glycoprotein Ib alpha chain; platelet membrane glycoprotein 1b-alpha subunit

Reagents Provided

FAQs

No product specific FAQs exist for this product, however you may

View all cDNA Clone FAQs

Reviews for Human CD42b/GPIb alpha (NP_000164) VersaClone cDNA

There are currently no reviews for this product. Be the first to review Human CD42b/GPIb alpha (NP_000164) VersaClone cDNA and earn rewards!

Have you used Human CD42b/GPIb alpha (NP_000164) VersaClone cDNA?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review