Human CD43 Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: CD43

CD43, also known as Leukosialin and Sialophorin and Ly-48 in mouse, is a 100-105 kDa type I transmembrane sialylated mucin that is expressed on most leukocytes and some tumor cells. Notably, the membrane expression of CD43 seems to be a characteristic of leukocytes, while cytoplasmic expression without membrane insertion occurs in endothelium and select epithelia. While CD43 restricts leukocyte adhesion and modulates T cell activation, these activities are context specific. CD43 can both induce and protect against apoptosis, and can either promote or block cell adhesion. Mature CD43 shows 49% amino (aa) sequence identity between human and mouse.

Product Datasheets

Related Research Areas

• Airway Inflammation and Remodeling
• B Cell Activation
• B Cell Markers
• Basophils
• Dendritic Cell Adhesion and Migration
• Eosinophils
• Granulocyte Markers
• Leukocyte Receptors/Markers in Allergy and Asthma
• Monocyte Markers
• Mouse Tissue-Resident Macrophage Markers
• Myeloid-derived Suppressor Cells (MDSC)
• Neutrophils
• Special Glycoproteins
• T Cell Migration/Adhesion