Human ChemR23 APC-conjugated Antibody

(1 citations)   
  • Species Reactivity
  • Specificity
    Detects human ChemR23. Stains human ChemR23-transfected cells but not irrelevant transfectants.
  • Source
    Monoclonal Mouse IgG3 Clone # 84939
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    NS0 mouse myeloma cell line transfected with human ChemR23
    Accession # NP_004063
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of ChemR23 in Human Whole Blood Monocytes by Flow Cytometry. Human whole blood monocytes were stained with Mouse Anti-Human IL-3 R alpha/CD123 PE‑conjugated Monoclonal Antibody (Catalog # FAB301P) and either (A) Mouse Anti-Human ChemR23 APC‑conjugated Monoclonal Antibody (Catalog # FAB362A) or (B) Mouse IgG3 Allophycocyanin Isotype Control (Catalog # IC007A). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: ChemR23
ChemR23, also known as CMKLR1, is a 47-48 kDa 7-transmembrane member of the rhodopsin, or G-protein coupled receptor family 1. It has restricted expression on select cell types that, in primate, include adipocytes, astrocytes, endothelial cells, microglia/macrophages, chondrocytes, monocytes, osteocytes, NK cells, and plasmacytoid plus myeloid dendritic cells. In mouse, would studies show ChemR23 to be expressed by neutrophils and keratinocytes. The universally-agreed on ligand for ChemR23 is Chemerin, a 137 amino acid (aa) non-chemokine product of fibroblasts, platelets, adipocytes and endothelium. The Chermerin:ChemR23 system is suggested to promote chemotaxis for all ChemR23+ cells, and to induce angiogenesis via endothelial cell migration and MMP-2 and -9 activation. There is one alternative splice form that shows a deletion of aa 1 and 2 (NP_004063). Over the extracellular domains of ChemR23, human and mouse share 69% aa sequence identity.
  • References:

  • Long Name:
    Chemokine-like Receptor 1/Orphan G Protein-coupled Receptor ChemR23
  • Entrez Gene IDs:
    1240 (Human); 14747 (Mouse); 60669 (Rat)
  • Alternate Names:
    CHEMERINR; chemokine receptor-like 1; chemokine-like receptor 1; CHEMR23; cmklr1; Dez; Gpcr27; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ; MGC126105; MGC126106; orphan G-protein coupled receptor, Dez
Related Research Areas

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Showing Results 1 - 1 of 1

  1. ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages.
    Authors: Herova M, Schmid M, Gemperle C, Hersberger M
    J Immunol, 2015;194(5):2330-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
Isotype Controls
Description Application Cat# Citations Images  

Mouse IgG3 APC-conjugated Antibody

Ctrl IC007A 1  
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Staining Reagents
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Flow Cytometry Staining Buffer (1X)

Flow FC001 3
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Flow Cytometry Mouse Lyse Buffer (10X)

Flow FC003 1
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Flow Cytometry Human Lyse Buffer (10X)

Flow FC002 1
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