Human CLCA1 Alexa Fluor® 647-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: CLCA1

CLCA1 is a member of the calcium sensitive chloride conductance protein family which may be involved in mediating calcium-activated chloride conductance.  This protein is expressed in goblet cells and intestinal basal crypt epithelial of the small intestine and colon. CLCA1 regulates mucin expression and participates in innate immune responses by binding to yet unidentified molecules on inflammatory cells for cytokine and chemokine production.  CLCA1 also targets lymphatic endothelial cells and cancer cells.  CLCA1 is a candidate as a modulating factor in the pathogenesis of mucus hypersecretory-associated respiratory and gastrointestinal diseases including asthma, COPD, cystic fibrosis, pneumonia, colon colitis, cystic fibrosis intestinal mucous disease, ulcerative colitis, and gastrointestinal parasitic infection.

Product Datasheets

Related Research Areas

• Chloride Channels
• Ion Channels and Regulators