Human CLCA1 Alexa Fluor™ Plus 488‑conjugated Antibody

R&D Systems | Catalog # FAB10766AFP488

R&D Systems

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # 1022517
View all CLCA1 Primary Antibodies »

Product Specifications

Specificity

Detects CLCA1 in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Human CLCA1 Alexa Fluor™ Plus 488‑conjugated Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: CLCA1

CLCA1 is a member of the calcium sensitive chloride conductance protein family which may be involved in mediating calcium-activated chloride conductance.  This protein is expressed in goblet cells and intestinal basal crypt epithelial of the small intestine and colon. CLCA1 regulates mucin expression and participates in innate immune responses by binding to yet unidentified molecules on inflammatory cells for cytokine and chemokine production.  CLCA1 also targets lymphatic endothelial cells and cancer cells.  CLCA1 is a candidate as a modulating factor in the pathogenesis of mucus hypersecretory-associated respiratory and gastrointestinal diseases including asthma, COPD, cystic fibrosis, pneumonia, colon colitis, cystic fibrosis intestinal mucous disease, ulcerative colitis, and gastrointestinal parasitic infection.

Long Name

Chloride Channel Accessory 1

Alternate Names

CaCC-1, CLCRG1, GOB5, HCLCA1

Entrez Gene IDs

1179 (Human); 23844 (Mouse); 308015 (Rat)

Gene Symbol

CLCA1

UniProt

A8K714

Additional CLCA1 Products

Product Documents for Human CLCA1 Alexa Fluor™ Plus 488‑conjugated Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human CLCA1 Alexa Fluor™ Plus 488‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

Related Research Areas

Ion Channels and Regulators

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Protocols

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FAQs

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