Human CXCR5 (NP_001707) VersaClone cDNA

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R&D Systems VersaClone cDNA Plasmids
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Human CXCR5 (NP_001707) VersaClone cDNA Summary


Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: CXCR5

CXCR5, also known as Burkitt Lymphoma Receptor 1, is a G protein-coupled receptor (GPCR) member of the CXC subfamily of chemokine receptors. Human CXCR5 is 372 amino acids (aa) in length with a predicted molecular weight of 42 kDa. Mouse and rat CXCR5 share 83% and 81% aa sequence identity with the human protein, respectively. CXCR5 is primarily expressed on B cells and binds CXCL13/BCL/BCA-1. The CXCL13/BCL/BCA-1:CXCR5 axis regulates B cell migration within secondary lymphoid organs such as the spleen and Peyer’s patches. CXCR5 is also expressed on follicular helper T cells and dermal-derived migratory dendritic cells where it is thought to promote the humeral immune response by meditating germinal center reactions and B cell activation. Polymorphisms of CXCR5 are associated with multiple types of non-Hodgkin’s lymphoma, and it is expressed on Burkitt’s lymphoma cells.

Entrez Gene IDs
643 (Human); 12145 (Mouse); 29363 (Rat)
Alternate Names
BLR1; BLR1MDR-15; Burkitt lymphoma receptor 1; Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif)receptor 5); Burkitt lymphoma receptor 1, GTP-binding protein; CD185 antigen; CD185; chemokine (C-X-C motif) receptor 5; C-X-C chemokine receptor type 5; CXCR5; CXC-R5; MDR15CXCR-5; MGC117347; Monocyte-derived receptor 15


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