Human Cyclin E2 Alexa Fluor® 594-conjugated Antibody

Catalog #: FAB7444T Datasheet / COA / SDS

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FAB7444T-100UG

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Human Cyclin E2 Alexa Fluor® 594-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Cyclin E2 in direct ELISAs.

Source

Monoclonal Mouse IgG2b Clone # 718916

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human Cyclin E2
Met1-Gln140
Accession # O96020

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 594 (Excitation= 590 nm, Emission= 617 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Cyclin E2

Cyclin E2, also known as CCNE2, is an approximately 45-50 kDa protein that associates with the kinase Cdk2. This complex phosphorylates multiple substrates involved in regulation of cell cycle progression and the initiation of DNA replication. Cyclin E2 is required for G1/S phase progression and cell cycle reentry from G0 phase. Cyclin E2 most highly expressed in testis, thymus, and brain and is frequently upregulated in cancer. Cyclin E2 contains two cyclin box folds (amino acids 141-231 and amino acids 241-361). An alternate splice form lacks 45 amino acids (aa) within the first cyclin box fold. Within aa 1-140, human Cyclin E2 shares 90% aa sequence identity with mouse and rat Cyclin E2.

Entrez Gene IDs

9134 (Human); 12448 (Mouse); 362485 (Rat)

Alternate Names

CCNE2; CYCE2; Cyclin E2; G1/S-specific cyclin E2; G1/S-specific cyclin-E2