Human Daxx Alexa Fluor™ Plus 555‑conjugated Antibody

R&D Systems | Catalog # AF4548AFP555

R&D Systems

Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Alexa Fluor Plus 555 (Excitation = 558 nm, Emission = 572 nm)

Antibody Source

Polyclonal Goat IgG
View all Daxx Primary Antibodies »

Product Specifications

Specificity

Detects endogenous human Daxx in Western blots. Detection of both reported Daxx isoforms is expected based on immunogen sequence.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Human Daxx Alexa Fluor™ Plus 555‑conjugated Antibody

Application
Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Daxx

Daxx (Fas death domain-associated-xx; also death domain-associated protein 6) is a ubiquitously expressed, proapoptotic protein that belongs to the Daxx family of molecules. Although it has a predicted MW of 81 kDa, it runs anomously at 110 kDa in SDS-PAGE. Daxx is found in the nucleus where it represses transcription. In the cytoplasm, it binds to ASK1, where it mediates Fas-induced apoptosis. Human Daxx is 740 amino acids (aa) in length and contains three coiled-coil regions (aa 180‑217; 358‑399; 430‑489), two NLSs, and an Asp/Glu-rich acidic region (aa 434‑572). One splice variant is known that shows a 15 aa substitution for aa 696‑740. Human Daxx shares 71% and 90% aa identity with mouse and dog Daxx, respectively.

Long Name

Fas Death Domain-associated Protein

Alternate Names

BING2, DAP6

Entrez Gene IDs

1616 (Human); 13163 (Mouse); 140926 (Rat)

Gene Symbol

DAXX

UniProt

Q9UER7

Additional Daxx Products

Product Documents for Human Daxx Alexa Fluor™ Plus 555‑conjugated Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human Daxx Alexa Fluor™ Plus 555‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

Related Research Areas

Apoptosis Adaptor Proteins

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