Human FCRL2/FcRH2 APC-conjugated Antibody

Clone 296902 was used by HLDA to establish CD designation
Datasheet / CoA / SDS
Product Details
Supplemental Products
  • Species Reactivity
  • Specificity
    Detects human FCRL2/FcRH2 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) FCRL1, 3, 4, or 5 is observed.
  • Source
    Monoclonal Mouse IgG1 Clone # 296902
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    Mouse myeloma cell line NS0-derived recombinant human FCRL2/FcRH2
    Accession # Q96LA5
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
Product Datasheets

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Certificate of Analysis Lookup

Certificate of Analysis Request Form

To download a Certificate of Analysis, please enter the catalog and lot numbers in the search box below.

Note: Certificate of Analysis not available for kit components.

  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Example
Detection of FCRL2/FcRH2 in CD19+ Human Lymphocytes by Flow Cytometry. CD19+ human lymphocytes were stained with Mouse Anti-Human FCRL2/FcRH2 APC‑conjugated Monoclonal Antibody (Catalog # FAB2048A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: FCRL2/FcRH2

Fc Receptor-Like 2 (FCRL2), also known as FcRH2 and IRTA4, belongs to the family of glycoprotein homologs of classical immunoglobulin (Ig) Fc receptors. In human, the type I transmembrane FCRL protein family contains from three to nine immunoglobulin-like domains (1, 2). Mature human FcRH2 consists of a 382 amino acid (aa) extracellular domain (ECD) with four Ig-like C2-set domains, a 21 aa transmembrane segment, and an 86 aa cytoplasmic domain with one ITAM-like, and two ITIM-like motifs (3-5). Alternate splicing of human FCRL2 may generate isoforms with N-terminal, internal, or C-terminal deletions (4, 5). The gene for FcRH2 maps to the human Iq21-23 locus which is a hotspot for chromosomal translocation events associated with B cell malignancies (3, 6). Although there are several Fc receptor-like genes in the mouse, none of these is a clear ortholog to human FCRL2 (7). FCRL proteins are differentially expressed among B cells (2). FCRL2 is preferentially expressed on naïve and CD27+ memory B cells within the spleen, lymph nodes, tonsils, and peripheral blood (3, 4, 8, 9). It is also expressed on most B cells in B cell chronic lymphocytic leukemia (B-CLL) patients (10). FCRL2 upregulation is associated with mutation of the Immunoglobulin Heavy Chain Variable (IGHV) and less aggressive forms of B-CLL (9, 11).


  • References:
    1. Maltais, L.J. et al. (2006) Nat. Immunol. 7:431.
    2. Davis, R.S. et al. (2007) Annu. Rev. Immunol. 25:525.
    3. Miller, I. et al. (2002) Blood 99:2662.
    4. Davis, R.S. et al. (2001) Proc. Natl. Acad. Sci. 98:9772.
    5. Xu, M.J. et al. (2001) Biochem. Biophys. Res. Commun. 280:768.
    6. Hatzivassiliou, G. et al. (2001) Immunity 14:277.
    7. Davis, R.S. et al. (2004) Int. Immunol. 16:1343.
    8. Polson, A.G. et al. (2006) Int. Immunol. 18:1363.
    9. Huttmann, A. et al. (2006) Leukemia 20:1774.
    10. Kazemi, T. et al. (2008) Int. J. Cancer 123:2113.
    11. Li, F.J. et al. (2008) Blood 112:179.
  • Long Name:
    Fc Receptor-like 2
  • Entrez Gene IDs:
    79368 (Human)
  • Alternate Names:
    CD307b antigen; CD307b; Fc receptor homolog 2; Fc receptor-like 2; FcRH2; FCRH2SPAP1B; FCRL2; FcR-like protein 2; IFGP family protein 4; IFGP4; Immunoglobulin receptor translocation-associated protein 4; immunoglobulin superfamily Fc receptor, gp42; IRTA4; IRTA4SPAP1C; SH2 domain containing phosphatase anchor protein 1; SH2 domain-containing phosphatase anchor protein 1Fc receptor-like protein 2; SPAP1; SPAP1A; SPAP1immune receptor translocation-associated protein 4
Related Research Areas


No product specific FAQs exist for this product, however you may

View all Antibody FAQs
Isotype Controls
Description Application Cat# Citations Images  

Mouse IgG1 APC-conjugated Antibody

Ctrl IC002A 11  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
Staining Reagents
Description Application Cat# Citations Images  

Flow Cytometry Staining Buffer (1X)

Flow FC001 7
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Flow Cytometry Mouse Lyse Buffer (10X)

Flow FC003 5
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Flow Cytometry Human Lyse Buffer (10X)

Flow FC002 1
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Have you used Human FCRL2/FcRH2 APC-conjugated Antibody?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Order Details

Contact Us to Order


Customer Information

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Panels For

Learn More
Monoclonal Antibodies
R&D Systems Guarantee