Human Glucagon R/GCGR Alexa Fluor® 488-conjugated Antibody

Catalog # Availability Size / Price Qty
FAB10296G-100UG
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Human Glucagon R/GCGR Alexa Fluor® 488-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human Glucagon R/GCGR in direct ELISAs.
Source
Monoclonal Mouse IgG2A Clone # 591929
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
HEK293 human embryonic kidney cell line transfected with human Glucagon R/GCGR
Met1-Gln142
Accession # P47871
Formulation
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Label
Alexa Fluor 488 (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
0.25-1 µg/106 cells
HEK293 Human Cell Line Transfected with Human Glucagon R/GCGR and eGFP

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: Glucagon R/GCGR

GLR (GCGR/Glucagon Receptor) is a GPCR for glucagon that plays a role in blood glucose levels and glucose homeostasis. Glucagon receptors are mainly expressed in liver and kidney but also expressed in other tissues such as heart, adipose, spleen, thymus, adrenal glands, pancreas, cerebral cortex and the gastrointestinal tract. Mutations in the GCGR gene is associated with Type 2 Diabetes Mellitus and inactivation of the receptor causes glucagon resistance. GCGR is found on the cell membrane but is rapidly internalized following ligand-binding via endocytosis.

Long Name
Glucagon Receptor
Entrez Gene IDs
2642 (Human); 14527 (Mouse)
Alternate Names
FLJ97182; GCGR; GGR; GLR; GL-R; Glucagon R; glucagon receptor; GlucagonR; MGC138246

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