Human GluR2 Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: GluR2

GluR2 is a receptor for glutamate.  Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain. The subunit encoded by this gene (GRIA2) is subject to RNA editing which renders the receptor it becomes part of impermeable to calcium ions.  This editing occurs at the Q/R site at a frequency of 100% of GluR2 transcripts in the brain.  The main function of this editing is regulation of electrophysiology of the receptor channel.  Defective editing of this channel has been linked to several conditions such as ALS, Epilepsy and some human brain tumors.  GRIA2 is a diagnostic immunochemical marker for solitary fibrous tumor which distinguishes it from most mimics.

Product Datasheets

Related Research Areas

• Glutamate Receptors