GPR31 is a plasma membrane G protein-coupled receptor (GPCR) that displays high affinity for 12-lipoxygenase-derived product 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-(S)-HETE). Knocking down GPR31 specifically inhibited 12-(S)-HETE-stimulated cell invasion. The diverse biological activities mediated by 12-(S)-HETE suggest that it functions as a critical signaling molecule in the regulation of physiological processes. 12-(S)-HETE/GPR31 binding leads to the activation of ERK1/2, MEK, and NF-kB.
Human GPR31 (EAW47505) VersaClone cDNA
R&D Systems | Catalog # RDC0645
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: GPR31
Long Name
G-Protein-Coupled Receptor 31
Alternate Names
12-HETER, HETER1
Gene Symbol
GPR31
UniProt
Additional GPR31 Products
Product Documents for Human GPR31 (EAW47505) VersaClone cDNA
Certificate of Analysis
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Product Specific Notices for Human GPR31 (EAW47505) VersaClone cDNA
For research use only
Related Research Areas
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