Human HIC5/TGFB1I1 Alexa Fluor® 594-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: HIC5/TGFB1I1

HIC5 (Hydrogen peroxide inducible clone 5; also ARA55) is a 50-55 kDa group III member of the LIM domain family of proteins. It is expressed primarily in smooth muscle, platelets and myoepithelium. It resides in both cytoplasm and nucleus, and performs multiple functions. It associates with focal adhesions, binds to the nuclear matrix, and serves as a coactivator for the glucocorticoid and androgen receptors. Human HIC5 is 461 amino acids (aa) in length. It contains four Leu:Asp‑rich motifs (aa 1‑215) and four LIM domains (aa 226‑461). LIM domains, either individually, or in combination, perform the majority of functions. LIM4 binds to the nuclear matrix, LIMs 3 and 4 are coactivators, and LIMs 2 and 3 bind to focal adhesions. HIC5 is induced by TGF beta and by hydrogen peroxide.

Product Datasheets

Related Research Areas

• Actin Stress Fibers and Focal Adhesions During EMT
• Focal Adhesions
• Steroid Hormone Receptor Regulators
• Steroid Hormone Receptors and Regulators
• TGF-beta Family
• Wnt Intracellular Signaling