Human ICAM-1/CD54 (NP_000192) VersaClone cDNA
Human ICAM-1/CD54 (NP_000192) VersaClone cDNA Summary
ICAM-1 (intercellular adhesion molecule-1), also known as CD54, is a transmembrane protein that is upregulated on endothelial and epithelial cells at sites of inflammation. It mediates the vascular adhesion and paracellular migration of leukocytes expressing activated LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). It also binds several non-integrin ligands including CD43/Sialophorin, Fibrinogen, Hyaluronan, rhinoviruses, and Plasmodium falciparum-infected erythrocytes. Soluble ICAM-1 promotes angiogenesis and serves an indicator of vascular endothelial cell activation or damage. Elevated levels of soluble ICAM-1 are associated with cardiovascular disease, type 2 diabetes, organ transplant dysfunction, oxidant stress, increased abdominal fat mass, hypertension, liver disease, certain malignancies, and cerebral malaria.
Citation for Human ICAM-1/CD54 (NP_000192) VersaClone cDNA
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1 Citation: Showing 1 - 1
NANOG helps cancer cells escape NK cell attack by downregulating ICAM1 during tumorigenesis
Authors: K Saga, J Park, K Nimura, N Kawamura, A Ishibashi, N Nonomura, Y Kaneda
J. Exp. Clin. Cancer Res., 2019;38(1):416. 2019
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