Human IL-3R alpha/CD123 Alexa Fluor® 647-conjugated Antibody Summary
Accession # P26951
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
Background: IL-3R alpha
IL-3 is a pleiotropic cytokine that can stimulate proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors (1, 2). IL-3 exerts its activity through binding to a specific cell surface receptor known as IL-3 R. IL-3 R is a heterodimeric structure composed of a 70 kDa IL-3 R alpha subunit (CD123) and a 120-140 kDa IL-3 R beta subunit (CD131) (3, 4). IL-3 R alpha binds IL-3 with relatively low affinity. In the presence of IL-3 R beta, however, IL-3 R alpha has a much higher affinity for IL-3. It is not clear how signal transduction occurs following IL-3 binding. The IL-3 R alpha chain has a very short intracellular domain while the IL‑3 R beta chain has a very large cytoplasmic domain. The IL‑3 R beta chain is also shared by the receptors for IL-5 and GM-CSF. Cells known to express IL-3 receptors include hematopoietic progenitors, epithelial cells, double negative T cells, mast cells, basophils and blood monocytes (5).
- Moore, M.A.S. et al. (1991) Blood 72:944.
- Warren, D.J. et al. (1988) J. Immunol. 140:94.
- Plant M. et al. (1989) Nature 339:150.
- Budel, L.M. et al. (1990) Blood 75:1439.
- Schrader, J.W. et al. (1988) In Interleukin-3: The Panspecific hemopoietin (ed. J.W. Schrader), Academic Press, San Diego, CA.
No product specific FAQs exist for this product, however you mayView all Antibody FAQs
Reviews for Human IL-3R alpha/CD123 Alexa Fluor® 647-conjugated Antibody
There are currently no reviews for this product. Be the first to review Human IL-3R alpha/CD123 Alexa Fluor® 647-conjugated Antibody and earn rewards!
Have you used Human IL-3R alpha/CD123 Alexa Fluor® 647-conjugated Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image