Human KA1/GRIK4 Alexa Fluor® 488-conjugated Antibody

Catalog #: FAB11326G Datasheet / COA / SDS

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FAB11326G-100UG

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All KA1/GRIK4 Antibodies

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Human KA1/GRIK4 Alexa Fluor® 488-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human KA1/GRIK in direct ELISA.

Source

Monoclonal Mouse IgG2b Clone # 1060003

Purification

Protein A or G purified

Immunogen

Human KA1/GRIK containing peptide
Accession # P42263

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 488 (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: KA1/GRIK4

GRIK4 (Glutamate receptor, ionotropic kainate 4) is a receptor for glutamate and is one of the 5 types of kainate receptor subunits. Glutamate acts as an excitatory neurotransmitter at many synapses in the CNS are key mediators of brain communication. Kainate receptors are relevant targets for neuroprotection of both neurons and glia in acute and chronic neurodegerative diseases. They are also involved in epilepsy, pain and psychiatric disorders. Variations in GRIK4 have been associated with both increased and decreased risk of bipolar disorder. Single-nucleotide polymorphism's in GRIK 4 are also observed in Schizophrenia.

Long Name

Glutamate Receptor KA1

Entrez Gene IDs

2900 (Human); 110637 (Mouse); 24406 (Rat)

Alternate Names

EAA1; Excitatory amino acid receptor 1; GluK4; glutamate receptor KA1; Glutamate receptor KA-1; glutamate receptor, ionotropic kainate 4; glutamate receptor, ionotropic, kainate 4; GRIK4; KA1; KA1GRIK