|Detection of KIR2DS1/CD158h in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Rabbit Anti-Human KIR2DS1/CD158h Alexa Fluor® 488‑conjugated Monoclonal Antibody (Catalog # FAB8887G) and either (A) Mouse Anti-Human NCAM‑1/CD56 PE‑conjugated Monoclonal Antibody (Catalog # FAB2408P) or (B) Mouse Anti-Human KIR2DL1/KIR2DS5 PE‑conjugated Monoclonal Antibody (Catalog # FAB1844P). View our protocol for Staining Membrane-associated Proteins.|
The KIRs comprise a family of 14 polymorphic and homologous activating and inhibitory receptors expressed primarily on CD56dim NK cells. KIR2DS1 is an activating receptor with high homology to the inhibitory receptor KIR2DL1. Both KIR2DL1 and KIR2DS1 bind to HLA-C alleles containing the C2 epitope. KIR2DS1 and KIR2DL1 expression regulates NK cell licensing and activation in a number of immune contexts. Over amino acids (aa) 1-245, human KIR2DS1 shares 97% aa sequence identity with human KIR2DL1.
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