Human KIR2DS1/CD158h Alexa Fluor® 647-conjugated Antibody

Recombinant Monoclonal Antibody
    
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  • Species Reactivity
    Human
  • Specificity
    Detects human KIR2DS1/CD158h in flow cytometry. Clone 1127B recognizes KIR2DS1 and some alleles of KIR2DL1, both members of the killer cell immunoglobulin-like receptor (KIR) family. Because Clone 1127B displays partial cross-reactivity with KIR2DL1, co-staining with Mouse Anti-Human KIR2DL1 Clone 143211 (Catalog # FAB1844P) is recommended.
  • Source
    Recombinant Monoclonal Rabbit IgG Clone # 1127B
  • Purification
    Protein A or G purified from cell culture supernatant
  • Immunogen
    HEK293 human embryonic kidney cell line transfected with human KIR2DS1/CD158h
    Met1-His245
    Accession # Q14954
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
    Alexa Fluor 647
Product Datasheets

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Applications
  •  
    Recommended
    Concentration
    Sample
  • Flow Cytometry
    5 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Example
Detection of KIR2DS1/CD158h in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Rabbit Anti-Human KIR2DS1/CD158h Alexa Fluor® 647‑conjugated Monoclonal Antibody (Catalog # FAB8887R) and either (A) Mouse Anti-Human KIR2DL1/KIR2DS5 PE‑conjugated Monoclonal Antibody (Catalog # FAB1844P) or (B) Mouse Anti-Human NCAM‑1/CD56 PE‑conjugated Monoclonal Antibody (Catalog # FAB2408P). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: KIR2DS1/CD158h

The KIRs comprise a family of 14 polymorphic and homologous activating and inhibitory receptors expressed primarily on CD56dim NK cells. KIR2DS1 is an activating receptor with high homology to the inhibitory receptor KIR2DL1. Both KIR2DL1 and KIR2DS1 bind to HLA-C alleles containing the C2 epitope. KIR2DS1 and KIR2DL1 expression regulates NK cell licensing and activation in a number of immune contexts. Over amino acids (aa) 1-245, human KIR2DS1 shares 97% aa sequence identity with human KIR2DL1.

  • Long Name:
    Killer Cell Immunoglobulin-like Receptor, Two Domains, Short Cytoplasmic Tail, 1
  • Entrez Gene IDs:
    3806 (Human)
  • Alternate Names:
    killer cell immunoglobulin-like receptor 2DS1; CD158a; CD158h; EB6ActI; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1; KIR2DS1; p50.1
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Rabbit IgG Alexa Fluor® 647-conjugated Antibody

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