Human KOR PE‑conjugated Antibody

R&D Systems | Catalog # FAB3895P

R&D Systems
Discontinued Product
FAB3895P has been discontinued. View all KOR products.

Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Phycoerythrin (Excitation = 488 nm, Emission = 565-605 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # 387301
View all KOR Primary Antibodies »

Product Specifications

Immunogen

NS0 mouse myeloma cell line transfected with human KOR
Met1-Val380
Accession # P41145

Specificity

Stains human KOR transfectants but not irrelevant transfectants in flow cytometry.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Human KOR PE‑conjugated Antibody

Detection of KOR antibody in HEK293 Human Cell Line Transfected with human KOR and eGFP antibody by Flow Cytometry.

Detection of KOR in HEK293 Human Cell Line Transfected with human KOR and eGFP by Flow Cytometry.

HEK293 human embryonic kidney cell line transfected with human KOR and eGFP was stained with Mouse Anti-Human KOR PE-conjugated Monoclonal Antibody (Catalog # FAB3895P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Applications for Human KOR PE‑conjugated Antibody

Application
Recommended Usage

Flow Cytometry

10 µL/106 cells
Sample: HEK293 human embryonic kidney cell line transfected with human KOR and eGFP

Spectra Viewer

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.

Background: KOR

KOR ( kappa -Opioid Receptor) is a 45-58 kDa 7TM glycoprotein receptor that belongs to the Class A (Rhodopsin) family of GPCRs. It exists on the cell surface as either a monomer or heterodimer with the mu-Opioid Receptor (in females), and binds dynorphins. Activation of KOR impacts the release of neurotransmitters such as GABA, glutamate and dopamine. In the case of dopamine, it inhibits its release, blocking reward feedback effects associated with drug abuse. Its negative regulation is not limited to reward centers, however, as KOR activation also interrupts thermal, visceral and inflammatory-induced pain. Neurons and axonal projections from the dorsal raphe, ventral tegmentum, amygdala and nucleus accumbens have all been found to express KOR isoforms. The human KOR extracellular domains share 90% amino acid sequence identity with mouse KOR extracellular domains.

Long Name

Kappa Opioid Receptor

Alternate Names

OPRK1, Oprk2, R21

Entrez Gene IDs

4986 (Human); 18387 (Mouse); 29335 (Rat)

Gene Symbol

OPRK1

UniProt

P41145

Additional KOR Products

Product Documents for Human KOR PE‑conjugated Antibody

Certificate of Analysis

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Product Specific Notices for Human KOR PE‑conjugated Antibody

For research use only

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