Human KOR PE-conjugated Antibody

  • Species Reactivity
  • Specificity
    Stains human KOR transfectants but not irrelevant transfectants in flow cytometry.
  • Source
    Monoclonal Mouse IgG1 Clone # 387301
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    NS0 mouse myeloma cell line transfected with human KOR
    Accession # P41145
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of KOR in HEK293 Human Cell Line Transfected with human KOR and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with human KOR and eGFP was stained with Mouse Anti-Human KOR PE‑conjugated Monoclonal Antibody (Catalog # FAB3895P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: KOR
KOR ( kappa -Opioid Receptor) is a 45-58 kDa 7TM glycoprotein receptor that belongs to the Class A (Rhodopsin) family of GPCRs. It exists on the cell surface as either a monomer or heterodimer with the mu-Opioid Receptor (in females), and binds dynorphins. Activation of KOR impacts the release of neurotransmitters such as GABA, glutamate and dopamine. In the case of dopamine, it inhibits its release, blocking reward feedback effects associated with drug abuse. Its negative regulation is not limited to reward centers, however, as KOR activation also interrupts thermal, visceral and inflammatory-induced pain. Neurons and axonal projections from the dorsal raphe, ventral tegmentum, amygdala and nucleus accumbens have all been found to express KOR isoforms. The human KOR extracellular domains share 90% amino acid sequence identity with mouse KOR extracellular domains.
  • Long Name:
    Kappa Opioid Receptor
  • Entrez Gene IDs:
    4986 (Human); 18387 (Mouse); 29335 (Rat)
  • Alternate Names:
    kappa opioid receptor; kappa-type opioid receptor; KOR; K-OR-1; KOR-1; Opiate receptor, kappa-1; opioid receptor, kappa 1; OPRK; OPRK1; Oprk2; R21
Related Research Areas
Isotype Controls
Description Application Cat# Citations Images  

Mouse IgG1 PE-conjugated Antibody

Ctrl IC002P 28  
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Staining Reagents
Description Application Cat# Citations Images  

Flow Cytometry Staining Buffer (1X)

Flow FC001 3
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Flow Cytometry Mouse Lyse Buffer (10X)

Flow FC003 1
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Flow Cytometry Human Lyse Buffer (10X)

Flow FC002 1
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