Detection of KOR in HEK293 Human Cell Line Transfected with human KOR and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with human KOR and eGFP was stained with Mouse Anti-Human KOR PE‑conjugated Monoclonal Antibody (Catalog # FAB3895P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
12 months from date of receipt, 2 to 8 °C as supplied.
KOR ( kappa -Opioid Receptor) is a 45-58 kDa 7TM glycoprotein receptor that belongs to the Class A (Rhodopsin) family of GPCRs. It exists on the cell surface as either a monomer or heterodimer with the mu-Opioid Receptor (in females), and binds dynorphins. Activation of KOR impacts the release of neurotransmitters such as GABA, glutamate and dopamine. In the case of dopamine, it inhibits its release, blocking reward feedback effects associated with drug abuse. Its negative regulation is not limited to reward centers, however, as KOR activation also interrupts thermal, visceral and inflammatory-induced pain. Neurons and axonal projections from the dorsal raphe, ventral tegmentum, amygdala and nucleus accumbens have all been found to express KOR isoforms. The human KOR extracellular domains share
90% amino acid sequence identity with mouse KOR extracellular domains.
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