Human LAP (TGF-beta 1) Alexa Fluor® 350-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: LAP (TGF-beta 1)

The TGF-beta family includes several related proteins (70-80% sequence homology) from mammalian, avian, or Xenopus systems that are now designated TGF-beta 1, TGF‑ beta 2, TGF-beta 1.2, TGF-beta 3, TGF-beta 4, and TGF-beta 5. These proteins are secreted by cells in the form of an inactive complex, referred to as latent TGF-beta, that consists of TGF-beta associated non-covalently with a Latency-associated peptide (LAP). These two proteins are synthesized as a single pro-peptide that is cleaved in a post Golgi compartment prior to secretion. Different TGF-beta family members are naturally associated with their own distinct LAPs.

Product Datasheets

Related Research Areas

• Airway Inflammation and Remodeling
• Cytokines and Receptors in Angiogenesis
• gamma delta T Cells
• Multiple Sclerosis and Myelin Related Molecules
• Myeloid-derived Suppressor Cells (MDSC)
• Platelet Cytokine and Growth Factor Receptors
• T Cell Cytokine Signaling
• TGF-beta Family
• TGF-beta Family Ligands
• Th17 Cells
• Th22 Cells
• Th9 Cells