Human mGluR2 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB46761R Datasheet / COA / SDS

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FAB46761R-100UG

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Human mGluR2 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human mGluR2 in direct ELISAs.

Source

Monoclonal Mouse IgG2b Clone # 455311

Purification

Protein A or G purified

Immunogen

Mouse myeloma cell line, NS0-derived human mGluR2
Glu19-Ser498
Accession # Q14416

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: mGluR2

Metabotropic glutamate receptor 2 (mGluR2, also known as GPRC1B and GRM2) is an 872 aa, predicted 96 kDa multipass G protein coupled inhibitory receptor (GPCR) belonging to group II of the metabotropic glutamate receptor family. The receptor functions as an autoreceptor for glutamate, that upon activation, inhibits the emptying of vesicular contents at the presynaptic terminal of glutamatergic neurons. It is localized largely on the presynaptic side of glutamatergic and other neurotransmitter synapses in areas of the forebrain. mGluR2 activity is potentially involved in some anxiety disorders. The long N‑terminal extracellular region of human mGluR2 (aa 1‑498) shares 97% aa identity with either mouse or rat mGluR2.

Long Name

Metabotropic Glutamate Receptor 2

Entrez Gene IDs

2912 (Human); 108068 (Mouse); 24415 (Rat)

Alternate Names

GLUR2; glutamate metabotropic receptor 2; glutamate receptor, metabotropic 2; GPRC1B; GPRC1Bmetabotropic glutamate receptor 2; GRM2; mGlu2; mGluR2; MGLUR2glutamate receptor homolog; mGluR7