Human MICA/B PE-conjugated Antibody

Catalog # Availability Size / Price Qty
FAB13001P-025
FAB13001P-100
Human MICA/B PE-conjugated Antibody in Data
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Product Details
Citations (7)
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Human MICA/B PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human MICA/B in direct ELISAs.
Source
Monoclonal Mouse IgG2A Clone # 159207
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
BaF3 mouse pro-B cell line transfected with human MICA
Accession # Q29983
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Flow Cytometry Detection of MICA/B antibody in K562 Human Cell Line antibody by Flow Cytometry. View Larger

Detection of MICA/B in K562 Human Cell Line by Flow Cytometry. K562 human chronic myelogenous leukemia cell line was stained with Mouse Anti-Human MICA/B PE-conjugated Monoclonal Antibody (Catalog # FAB13001P, filled histogram) or isotype control antibody (Catalog # IC003P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: MICA/B

MICA and MICB are stress-induced type I transmembrane proteins that function as ligands for NKG2D. They are distantly related to MHC class I proteins and are expressed on epithelial tumors and in response to infections.

Long Name
MHC Class I-related Protein A and B
Entrez Gene IDs
4276 (Human)
Alternate Names
MHC class I chain-related protein A; MHC class I chain-related protein B; MIC; MICA; MICA/B; MICB; PERB11; PERB11.1; PERB11.2

Product Datasheets

Citations for Human MICA/B PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

7 Citations: Showing 1 - 7
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  1. High glucose promotes pancreatic cancer cells to escape from immune surveillance via AMPK-Bmi1-GATA2-MICA/B pathway
    Authors: Q Duan, H Li, C Gao, H Zhao, S Wu, H Wu, C Wang, Q Shen, T Yin
    J. Exp. Clin. Cancer Res., 2019;38(1):192.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. Interleukin-15 stimulates natural killer cell-mediated killing of both human pancreatic cancer and stellate cells
    Authors: JRM Van Audena, J De Waele, E Marcq, J Van Loenho, E Lion, JMJ Van den Be, R Jesenofsky, A Masamune, G Roeyen, P Pauwels, F Lardon, M Peeters, ELJ Smits
    Oncotarget, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. NKG2D-directed cytokine-activated killer lymphocyte therapy combined with gemcitabine for patients with chemoresistant metastatic solid tumors.
    Authors: Morisaki T, Hirano T, Koya N, Kiyota A, Tanaka H, Umebayashi M, Onishi H, Katano M
    Anticancer Res, 2014;34(8):4529-38.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. An epithelial cell adhesion molecule- and CD3-bispecific antibody plus activated T-cells can eradicate chemoresistant cancer stem-like pancreatic carcinoma cells in vitro.
    Authors: Umebayashi M, Kiyota A, Koya N, Tanaka H, Onishi H, Katano M, Morisaki T
    Anticancer Res, 2014;34(8):4509-19.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. Valproic acid cooperates with hydralazine to augment the susceptibility of human osteosarcoma cells to Fas- and NK cell-mediated cell death.
    Authors: Yamanegi K, Yamane J, Kobayashi K
    Int. J. Oncol., 2012;41(1):83-91.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  6. Natural killer cells from children with type 1 diabetes have defects in NKG2D-dependent function and signaling.
    Authors: Qin H, Lee IF, Panagiotopoulos C, Wang X, Chu AD, Utz PJ, Priatel JJ, Tan R
    Diabetes, 2011;60(3):857-66.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  7. Combinatorial Cytotoxicity of Gemcitabine and Cytokine-activated Killer Cells in Hepatocellular Carcinoma via the NKG2D-MICA/B System.
    Authors: Morisaki T, Onishi H, Koya N
    Anticancer Res., 2011;31(7):2505-10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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