Human MMP-9 Quantikine ELISA Kit

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PDMP900
SMP900
DMP900
Control Products Available
Human MMP-9 ELISA Standard Curve
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Product Details
Procedure
Citations (164)
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Human MMP-9 Quantikine ELISA Kit Summary

Assay Type
Solid Phase Sandwich ELISA
Format
96-well strip plate
Assay Length
3.5 hours
Sample Type & Volume Required Per Well
Cell Culture Supernates (10 uL), Serum (10 uL), Platelet-poor Heparin Plasma (10 uL), Saliva (10 uL), Urine (100 uL)
Sensitivity
0.156 ng/mL
Assay Range
0.3 - 20 ng/mL (Cell Culture Supernates, Serum, Platelet-poor Heparin Plasma, Saliva, Urine)
Specificity
Natural and recombinant human 92 kDa Pro-MMP-9 and the 82 kDa active MMP-9
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
Interference
Interference observed with 1 or more available related molecules.

Product Summary

The Quantikine Human MMP-9 Immunoassay is a 3.5 hour solid phase ELISA designed to measure MMP-9 (92 kDa pro- and 82 kDa active forms but not the 65 kDa form) in cell culture supernates, saliva, serum, plasma, and urine. It is calibrated with CHO cell-expressed recombinant human pro-MMP-9 and the antibodies were raised against the recombinant factor. Natural human MMP-9 showed dose-response curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards, indicating that this kit can be used to determine relative mass values of natural human MMP-9.

Precision

Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision

Cell Culture Supernates, Serum, Platelet-poor Heparin Plasma, Saliva, Urine

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 40 40 40
Mean 0.833 2.04 11 0.972 2.35 12.2
Standard Deviation 0.017 0.039 0.316 0.077 0.184 0.845
CV% 2 1.9 2.9 7.9 7.8 6.9

Recovery

The recovery of Pro-MMP-9 spiked to three levels throughout the range of the assay was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Media (n=5) 97 85-104
Platelet-poor Heparin Plasma (n=5) 96 89-108
Saliva (n=4) 90 74-114
Serum (n=5) 95 91-99
Urine (n=5) 91 82-99

Linearity

To assess the linearity of the assay, samples spiked with or containing high concentrations of Pro-MMP-9 were diluted with Calibrator Diluent to produce samples with values within the dynamic range of the assay.
Human MMP-9 ELISA Linearity

Data Examples

Human MMP-9 ELISA Standard Curve

Product Datasheets

Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: MMP-9

Matrix metalloproteinases (MMPs), also called matrixins, constitute a family of zinc and calcium dependent endopeptidases that function in the breakdown of the extracellular matrix (ECM) and in the processing of a variety of molecules in different subcellular environments. They play an important role in many normal physiological processes such as embryonic development, morphogenesis, reproduction, and tissue remodeling (1, 2). They also participate in inflammatory and autoimmune disorders such as arthritis, cancer, and cardiovascular disease (3-5). While the amounts of newly synthesized MMPs are regulated mainly at the levels of transcription, the proteolytic activities of existing MMPs are controlled through both the activation of proenzymes or zymogens and the inhibition of active enzymes by endogenous inhibitors, alpha 2-Macroglobulin, and tissue inhibitors of metalloproteinases (TIMPs) (6). 

MMP-9 (also referred to as gelatinase B, 92 kDa type IV collagenase, 92 kDa gelatinase, and type V collagenase) is secreted as a glycosylated proenzyme (6-8). Activation of the proenzyme involves proteolytic removal of the N-terminal pro region, resulting in the 82 kDa active enzyme (9, 10). Active human MMP-9 shares 72% and 74% amino acid sequence identity with mouse and rat MMP-9, respectively. In addition to the zinc-binding site, the catalytic domain also contains three contiguous fibronectin type II homology units responsible for binding gelatin (11). A proline-rich hinge region links the catalytic domain to the C-terminal hemopexin-like domain. In vitro treatment of the proenzyme with 4-aminophenylmercuric acetate (APMA) produces not only the active enzyme but also a C-terminal truncated form with activity comparable to that of the active form (12). MMP-9 degrades components of the ECM with high specific activity for denatured collagens (gelatin). It can cleave native collagens of type III, IV, V, and XI, as well as Elastin, Nidogen-1, and Vitronectin (2, 3). MMP-9 can also cleave a variety of chemokines and growth factors (e.g. IL-1 beta, CXCL8/IL-8, CXCL7, CXCL4, CXCL1, Latent TGF-beta, membrane bound TNF-alpha, VEGF, and FGF basic), Amyloid beta peptide, Substance P, and Myelin Basic Protein (3, 13-15). This action can increase or decrease the biological activity of soluble factors and can also liberate them from association with the ECM (16, 17). MMP-9 can also trigger signaling through various transmembrane proteins or inhibit signaling by inducing their shedding from the cell surface (e.g. CD44, E-Cadherin, Integrins, ICAM-1, and IL-2 R alpha ) (3, 18-20). 
MMP-9 is produced by a variety of normal and transformed cells including neutrophils, monocytes, macrophages, astrocytes, fibroblasts, osteoclasts, chondrocytes, keratinocytes, endothelial and epithelial cells. It exerts physiological and pathological angiogenic and remodeling effects on the vasculature (21-25). Activated neutrophils release proMMP-9 which is free of TIMP-1, allowing the liberation of pro-angiogenic FGF-2 from the ECM (17). MMP-9 in complex with TIMP-1 does not induce FGF-2 release (17). Neutrophil-derived MMP-9 exacerbates the inflammatory response, in part by generating collagen-derived peptides that induce the release of additional neutrophil MMP9 (26). MMP-9 also plays a role in bone formation and remodeling (1, 21, 27), methamphetamineinduced behavioral sensitization and reward (28), the regulation of neuronal synapse remodeling (29), trophoblast invasion during implantation (30), and the inactivation of Serpin alpha 1-Proteinase Inhibitor (31). The shedding of adhesion proteins by MMP-9 has a direct effect on tumor cell invasiveness (18-20). 
Circulating levels of MMP-9 are increased in many inflammatory disorders including intraluminal thrombus formation (32), atherosclerosis (33), Crohn's disease (34), hepatitis C virus infection (35), colorectal cancer (36), and Duchenne muscular dystrophy (37). The ratio of MMP-9 to TIMP-1 is also increased in multiple sclerosis serum (38) and cystic fibrosis sputum (39), but it is decreased in the serum during cytomegalovirus infection (40). Levels of free MMP-9 and complexes of MMP-9 with Lipocalin-2/NGAL are elevated in the urine of ovarian cancer and uterine tract infection patients, respectively (41, 42).

Long Name:
Matrix Metalloproteinase 9
Entrez Gene IDs:
4318 (Human); 17395 (Mouse); 81687 (Rat)
Alternate Names:
92 kDa gelatinase; 92 kDa type IV collagenase; CLG4B; EC 3.4.24; EC 3.4.24.35; Gelatinase B; GELB; macrophage gelatinase; MANDP2; matrix metallopeptidase 9; matrix metalloproteinase 9; matrix metalloproteinase-9; MMP9; MMP-9; type V collagenase
⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Assay Procedure

Refer to the product for complete assay procedure.

Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
  1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
  2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.

  3. 100 µL Assay Diluent
  4.   Add 100 µL of Assay Diluent to each well.

  5. 100 µL Standard, Control, or Sample
  6.   Add 100 µL of Standard, control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours on a horizontal orbital microplate shaker.
  7.   Aspirate each well and wash, repeating the process 3 times for a total of 4 washes.

  8. 200 µL Conjugate
  9.   Add 200 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 1 hour on the shaker.
  10.   Aspirate and wash 4 times.

  11. 200 µL Substrate Solution
  12.   Add 200 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes on the benchtop. PROTECT FROM LIGHT.

  13. 50 µL Stop Solution
  14.   Add 50 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.

Citations for Human MMP-9 Quantikine ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

164 Citations: Showing 1 - 10
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  1. Genetic Target Modulation Employing CRISPR/Cas9 Identifies Glyoxalase 1 as a Novel Molecular Determinant of Invasion and Metastasis in A375 Human Malignant Melanoma Cells In Vitro and In Vivo
    Authors: J Jandova, J Perer, A Hua, JA Snell, GT Wondrak
    Cancers (Basel), 2020;12(6):.
    Species: Human
    Sample Types: cell culture supernatant
  2. Association of matrix metalloproteinase-9 polymorphism with severity of Guillain-Barr� syndrome
    Authors: S Hayat, O Ahmad, I Mahmud, MZH Howlader, Z Islam
    J. Neurol. Sci., 2020;415(0):116908.
    Species: Human
    Sample Types: Serum
  3. Activity of fibroblast-like synoviocytes in rheumatoid arthritis was impaired by dickkopf-1 targeting siRNA
    Authors: YY Liu, SY Wang, YN Li, WJ Bian, LQ Zhang, YH Li, L Long, X Liu, XW Zhang, ZG Li
    Chin. Med. J., 2020;0(6):679-686.
    Species: Human
    Sample Types: Cell Culture Supernates
  4. Diagnostic performance of serum interferon gamma, matrix metalloproteinases, and periostin measurements for pulmonary tuberculosis in Japanese patients with pneumonia
    Authors: M Yamauchi, T Kinjo, G Parrott, K Miyagi, S Haranaga, Y Nakayama, K Chibana, K Fujita, A Nakamoto, F Higa, I Owan, K Yonemoto, J Fujita
    PLoS ONE, 2020;15(1):e0227636.
    Species: Human
    Sample Types: Serum
  5. High serum levels of tissue inhibitor of matrix metalloproteinase-1 during the first week of a malignant middle cerebral artery infarction in non-surviving patients
    Authors: L Lorente, MM Martín, L Ramos, M Argueso, JJ Cáceres, J Solé-Violá, A Jiménez, JM Borreguero, AF González-R, J Orbe, JA Rodríguez, JA Páramo
    BMC Neurol, 2019;19(1):167.
    Species: Human
    Sample Types: Serum
  6. The prognostic value of the�Tau protein serum level in metastatic breast cancer patients and its correlation with brain metastases
    Authors: A Darlix, C Hirtz, S Thezenas, A Maceski, A Gabelle, E Lopez-Crap, H De Forges, N Firmin, S Guiu, W Jacot, S Lehmann
    BMC Cancer, 2019;19(1):110.
    Species: Human
    Sample Types: Serum
  7. Persistently high circulating tissue inhibitor of matrix metalloproteinase-1 levels in non-survivor brain trauma injury patients
    Authors: L Lorente, MM Martín, L Ramos, M Argueso, JJ Cáceres, J Solé-Violá, A Jiménez, JM Borreguero, AF González-R, J Orbe, JA Rodríguez, JA Páramo
    J Crit Care, 2019;51(0):117-121.
    Species: Human
    Sample Types: Serum
  8. Expression and Concentration of Matrix Metalloproteinase 9 and Tissue Inhibitor of Matrix Metalloproteinases 1 in Laryngeal Squamous Cell Carcinoma
    Authors: M Matulka, A Konopka, B Mroczko, A Pryczynicz, A Kemona, M Groblewska, A Sieskiewic, E Olszewska
    Dis. Markers, 2019;2019(0):3136792.
    Species: Human
    Sample Types: Plasma
  9. Effect of doxycyline in chronic obstructive pulmonary disease - An exploratory study
    Authors: B Singh, N Ghosh, D Saha, S Sarkar, P Bhattachar, K Chaudhury
    Pulm Pharmacol Ther, 2019;0(0):101831.
    Species: Human
    Sample Types: Plasma
  10. Small size apolipoprotein(a) isoforms enhance inflammatory and proteolytic potential of collagen-primed monocytes
    Authors: N Sabbah, S Jaisson, R Garnotel, E Anglés-Can, P Gillery
    Lipids Health Dis, 2019;18(1):166.
    Species: Human
    Sample Types: Cell Culture Supernates
  11. High serum levels of tissue inhibitor of matrix metalloproteinase-1 during the first week of a malignant middle cerebral artery infarction in non-surviving patients
    Authors: L Lorente, MM Martín, L Ramos, M Argueso, JJ Cáceres, J Solé-Violá, A Jiménez, JM Borreguero, AF González-R, J Orbe, JA Rodríguez, JA Páramo
    BMC Neurol, 2019;19(1):167.
    Species: Human
    Sample Types: Serum
  12. Effect of doxycyline in chronic obstructive pulmonary disease - An exploratory study
    Authors: B Singh, N Ghosh, D Saha, S Sarkar, P Bhattachar, K Chaudhury
    Pulm Pharmacol Ther, 2019;0(0):101831.
    Species: Human
    Sample Types: Plasma
  13. Basilar Artery Tortuosity Is Associated With White Matter Hyperintensities by TIMP-1
    Authors: DP Zhang, YF Peng, HL Zhang, JG Ma, M Zhao, S Yin, TT Wei
    Front Neurosci, 2019;13(0):836.
    Species: Human
    Sample Types: Plasma
  14. Levels of Selected Matrix Metalloproteinases, Their Inhibitors in Saliva, and Oral Status in Juvenile Idiopathic Arthritis Patients vs. Healthy Controls
    Authors: A Kobus, J Bagi?ska, J ?api?ska-A, S ?awicki, A Kierklo
    Biomed Res Int, 2019;2019(0):7420345.
    Species: Human
    Sample Types: Saliva
  15. Serum amyloid A1 polymorphisms as risk factors in oesophageal squamous cell carcinoma
    Authors: HL Lung, ML Lung, S Law
    Hong Kong Med J, 2019;25(5):4-8.
    Species: Human
    Sample Types: Plasma
  16. ADAMTS-5 Decreases in Coronary Arteries and Plasma from Patients with Coronary Artery Disease
    Authors: Z Wang, D Ye, J Ye, M Wang, J Liu, H Jiang, Y Xu, J Zhang, J Chen, J Wan
    Dis. Markers, 2019;2019(0):6129748.
    Species: Human
    Sample Types: Plasma
  17. Elevated Inflammatory Plasma Biomarkers in Patients With Fabry Disease: A Critical Link to Heart Failure With Preserved Ejection Fraction
    Authors: H Yogasundar, A Nikhanj, BN Putko, M Boutin, S Jain-Ghai, A Khan, C Auray-Blai, ML West, GY Oudit
    J Am Heart Assoc, 2018;7(21):e009098.
    Species: Human
    Sample Types: Plasma
  18. The role of pro-fibrotic biomarkers in paroxysmal and persistent atrial fibrillation
    Authors: AE Stanciu, RG Vatasescu, MM Stanciu, N Serdarevic, M Dorobantu
    Cytokine, 2018;103(0):63-68.
    Species: Human
    Sample Types: Serum
  19. Diagnostic power of VEGF, MMP-9 and TIMP-1 in patients with breast cancer. A multivariate statistical analysis with ROC curve
    Authors: M Zajkowska, E Gacuta, S Koz?owska, E Lubowicka, EK G?a?ewska, L Chrostek, M Szmitkowsk, P Paw?owski, M Zbucka-Kr?, S ?awicki
    Adv Med Sci, 2018;64(1):1-8.
    Species: Human
    Sample Types: Plasma
  20. Association of Polymorphisms of the Matrix Metalloproteinase 9 Gene with Ischaemic Stroke in a Southern Chinese Population
    Authors: Y Li, L Chen, S Yao, J Chen, W Hu, M Wang, S Chen, X Chen, S Li, X Gu, G Ma, B Zhao, W Zhong, K Li
    Cell. Physiol. Biochem., 2018;49(6):2188-2199.
    Species: Human
    Sample Types: Serum
  21. Zeylenone represses the progress of human prostate cancer by downregulating the Wnt/??catenin pathway
    Authors: S Zeng, B Zhu, J Zeng, W Wu, C Jiang
    Mol Med Rep, 2018;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  22. Changes in brain white matter structure are associated with urine proteins in urologic chronic pelvic pain syndrome (UCPPS): A MAPP Network study
    Authors: DC Woodworth, A Dagher, A Curatolo, M Sachdev, C Ashe-McNal, BD Naliboff, JS Labus, JR Landis, JJ Kutch, EA Mayer, RS Lee, MA Moses, BM Ellingson,
    PLoS ONE, 2018;13(12):e0206807.
    Species: Human
    Sample Types: Urine
  23. Activity of metalloproteinases and adiponectin in obese patients-a possible factor of incisional hernias after bariatric procedures
    Authors: W Szcz?sny, M Kuligowska, S D?browieck, J Szmytkowsk, A Re?li?ski, M S?upski
    J Zhejiang Univ Sci B, 2018;19(1):65-70.
    Species: Human
    Sample Types: Serum
    Applications: ELISA Capture
  24. Combination of Plasma Biomarkers and Clinical Data for the Detection of Myocardial Fibrosis or Aggravation of Heart Failure Symptoms in Heart Failure with Preserved Ejection Fraction Patients
    Authors: CK Wu, MM Su, YF Wu, JJ Hwang, LY Lin
    J Clin Med, 2018;7(11):.
    Species: Human
    Sample Types: Plasma
  25. Telmisartan inhibits Ang II-induced MMP-9 expression in macrophages in stabilizing atheromatous plaque
    Authors: ZJ Shen, CS Xu, YP Li, J Li, JJ Xu, P Xia
    Eur Rev Med Pharmacol Sci, 2018;22(22):8004-8012.
    Species: Human
    Sample Types: Cell Culture Supernates
  26. Association of urinary activity of MMP-9 with renal impairment in Mexican patients with type 2 diabetes mellitus
    Authors: AU García-Tej, CL Sampieri, I Suárez-Tor, J Morales-Ro, VP Demeneghi-, ME Hernández-, A Rodríguez-
    PeerJ, 2018;6(0):e6067.
    Species: Human
    Sample Types: Urine
  27. Does cardiac resynchronization therapy restore peripheral circulatory homeostasis?
    Authors: CN Ajaero, CR Chong, NEK Procter, S Liu, YY Chirkov, T Heresztyn, WPA Chan, MA Arstall, AD McGavigan, MP Frenneaux, JD Horowitz
    ESC Heart Fail, 2018;5(1):129-138.
    Species: Human
    Sample Types: Plasma
    Applications: ELISA Capture
  28. The Potential Role of Bile Acids in Acquired Laryngotracheal Stenosis
    Authors: A Aldhahrani, J Powell, S Ladak, M Ali, S Ali, B Verdon, J Pearson, C Ward
    Laryngoscope, 2018;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: ELISA Capture
  29. Mobilization of progenitor cells and assessment of vessel healing after second generation drug-eluting stenting by optical coherence tomography
    Authors: M Sakuma, T Nasuno, S Abe, S Obi, S Toyoda, I Taguchi, R Sohma, KI Inoue, S Nishino, K Node, G Attizzani, H Bezerra, M Costa, D Simon, T Inoue
    Int J Cardiol Heart Vasc, 2018;18(0):17-24.
    Species: Human
    Sample Types: Serum
  30. Nesfatin-1 and visfatin expression is associated with reduced atherosclerotic disease risk in patients with rheumatoid arthritis
    Authors: C Robinson, L Tsang, A Solomon, AJ Woodiwiss, S Gunter, M Mer, HC Hsu, M Gomes, GR Norton, AME Millen, PH Dessein
    Peptides, 2018;102(0):31-37.
    Species: Human
    Sample Types: Plasma
  31. How disease extent can be included in the endoscopic activity index of ulcerative colitis: the panMayo score, a promising scoring system
    Authors: A Bálint, K Farkas, Z Szepes, F Nagy, M Sz?cs, L Tiszlavicz, R Bor, Á Milassin, M Rutka, A Fábián, T Molnár
    BMC Gastroenterol, 2018;18(1):7.
    Species: Human
    Sample Types: Tissue Homogenates
  32. Influence of ethnic background on left atrial markers of inflammation, endothelial function and tissue remodelling
    Authors: CD Ruediger, B John, S Kumar, HS Lim, G Rangnekar, KC Roberts-Th, GD Young, D Chase, P Sanders, SR Willoughby
    Indian Pacing Electrophysiol J, 2018;18(1):1-5.
    Species: Human
    Sample Types: Serum
  33. Specific biomarkers of myocardial inflammation and remodeling processes as predictors of mortality in high-risk patients undergoing percutaneous mitral valve repair (MitraClip)
    Authors: O Dörr, C Walther, C Liebetrau, T Keller, H Tabert, N Boeder, M Bayer, P Bauer, H Möllmann, L Gaede, C Troidl, S Voss, T Bauer, CW Hamm, H Nef
    Clin Cardiol, 2018;0(0):.
    Species: Human
    Sample Types: Serum
  34. miR-302a-5p/367-3p-HMGA2 axis regulates malignant processes during endometrial cancer development
    Authors: J Ma, D Li, FF Kong, D Yang, H Yang, XX Ma
    J. Exp. Clin. Cancer Res., 2018;37(1):19.
    Species: Human
    Sample Types: Cell Culture Supernates
  35. Cerebrospinal fluid matrix metalloproteinase 9 levels, blood-brain barrier permeability, and treatment outcome in tuberculous meningitis
    Authors: S Mailankody, GV Dangeti, R Soundraval, NM Joseph, J Mandal, TK Dutta, T Kadhiravan
    PLoS ONE, 2017;12(7):e0181262.
    Species: Human
    Sample Types: CSF
  36. TIMP1 and MMP9 are predictors of mortality in septic patients in the emergency department and intensive care unit unlike MMP9/TIMP1 ratio: Multivariate model
    Authors: ME Niño, SE Serrano, DC Niño, DM McCosham, ME Cardenas, VP Villareal, M Lopez, A Pazin-Filh, FA Jaimes, F Cunha, R Schulz, D Torres-Due
    PLoS ONE, 2017;12(2):e0171191.
    Species: Human
    Sample Types: Serum
  37. Collagen turnover biomarkers and systemic right ventricle remodeling in adults with previous atrial switch procedure for transposition of the great arteries
    Authors: M Lipczy?ska, P Szyma?ski, M Kumor, A Klisiewicz, P Hoffman
    PLoS ONE, 2017;12(8):e0180629.
    Species: Human
    Sample Types: Serum
  38. Induced pluripotent stem cell-derived limbal epithelial cells (LiPSC) as a cellular alternative for in vitro ocular toxicity testing
    Authors: E Aberdam, I Petit, L Sangari, D Aberdam
    PLoS ONE, 2017;12(6):e0179913.
    Species: Human
    Sample Types: Cell Culture Supernates
  39. The crosstalk between vascular MSCs and inflammatory mediators determines the pro-calcific remodelling of human atherosclerotic aneurysm
    Authors: C Ciavarella, E Gallitto, F Ricci, M Buzzi, A Stella, G Pasquinell
    Stem Cell Res Ther, 2017;8(1):99.
    Species: Human
    Sample Types: Serum
  40. Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques
    Authors: SR Langley, K Willeit, A Didangelos, LP Matic, P Skroblin, J Barallobre, M Lengquist, G Rungger, A Kapustin, L Kedenko, C Molenaar, R Lu, T Barwari, G Suna, X Yin, B Iglseder, B Paulweber, P Willeit, J Shalhoub, G Pasterkamp, AH Davies, C Monaco, U Hedin, CM Shanahan, J Willeit, S Kiechl, M Mayr
    J. Clin. Invest, 2017;0(0):.
    Species: Human
    Sample Types: Plasma
  41. Late mitral restenosis after percutaneous commissurotomy: Predictive value of inflammation and extracellular matrix remodeling biomarkers
    Authors: R Mechmeche, A Zaroui, S Aloui, M Boukhris, M Allal-Elas, N Kaabachi, B Zouari
    Heart Lung, 2017;0(0):.
    Species: Human
    Sample Types: Serum
  42. Comparison of circulating dendritic cell and monocyte subsets at different stages of atherosclerosis: insights from optical coherence tomography
    Authors: J Zhuang, Y Han, D Xu, G Zhu, S Singh, L Chen, M Zhu, W Chen, Y Xu, X Li
    BMC Cardiovasc Disord, 2017;17(1):270.
    Species: Human
    Sample Types: Plasma
  43. Association of Toll-Like Receptor 4 on Human Monocyte Subsets and Vulnerability Characteristics of Coronary Plaque as Assessed by 64-Slice Multidetector Computed Tomography
    Authors: Y Ozaki, T Imanishi, S Hosokawa, T Nishiguchi, A Taruya, T Tanimoto, A Kuroi, T Yamano, Y Matsuo, Y Ino, H Kitabata, T Kubo, A Tanaka, T Akasaka
    Circ. J, 2017;0(0):.
    Species: Human
    Sample Types: Plasma
  44. Urinary kallikrein 10 predicts the incurability of gastric cancer
    Authors: T Shimura, M Ebi, T Yamada, T Yamada, T Katano, Y Nojiri, H Iwasaki, S Nomura, N Hayashi, Y Mori, H Kataoka, MA Moses, T Joh
    Oncotarget, 2017;8(17):29247-29257.
    Species: Human
    Sample Types: Urine
  45. Altered serum level of matrix metalloproteinase-9 and its association with decision-making in eating disorders
    Authors: J Matsumoto, Y Hirano, K Hashimoto, T Ishima, N Kanahara, T Niitsu, A Shiina, T Hashimoto, Y Sato, K Yokote, S Murano, H Kimura, Y Hosoda, E Shimizu, M Iyo, M Nakazato
    Psychiatry Clin. Neurosci., 2017;71(2):124-134.
    Species: Human
    Sample Types: Serum
  46. Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Preclinical evaluation and results of a randomized phase 2 trial
    Authors: VK Snowdon, NJ Lachlan, AM Hoy, PW Hadoke, SI Semple, D Patel, W Mungall, TJ Kendall, A Thomson, RJ Lennen, MA Jansen, CM Moran, A Pellicoro, P Ramachandr, I Shaw, RL Aucott, T Severin, R Saini, J Pak, D Yates, N Dongre, JS Duffield, DJ Webb, JP Iredale, PC Hayes, JA Fallowfiel
    PLoS Med, 2017;14(2):e1002248.
    Species: Human
    Sample Types: Serum
  47. Adipose progenitor cell secretion of GM-CSF and MMP9 promotes a stromal and immunological microenvironment that supports breast cancer progression
    Authors: F Reggiani, V Labanca, P Mancuso, C Rabascio, G Talarico, S Orecchioni, A Manconi, F Bertolini
    Cancer Res., 2017;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  48. Circulating tumor cells and serum levels of MMP-2, MMP-9 and VEGF as markers of the metastatic process in patients with high risk of metastatic progression
    Authors: M Skerenova, V Mikulova, O Capoun, T Zima, P Tesarova
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2017;0(0):.
    Species: Human
    Sample Types: Serum
  49. Molecular signatures of neutrophil extracellular traps in human visceral leishmaniasis
    Authors: LG Gardinassi, TS DeSouza-Vi, NO da Silva, GR Garcia, VM Borges, RNS Campos, RP de Almeida, IKF de Miranda, EM Saraiva
    Parasit Vectors, 2017;10(1):285.
    Species: Human
    Sample Types: Serum
  50. P2X7 receptor antagonism modulates IL-1? and MMP9 in human atherosclerotic vessels
    Authors: M Lombardi, ME Mantione, D Baccellier, D Ferrara, R Castellano, R Chiesa, O Alfieri, C Foglieni
    Sci Rep, 2017;7(1):4872.
    Species: Human
    Sample Types: Tissue Culture Supernates
  51. Differential diagnosis of lung cancer, its metastasis and chronic obstructive pulmonary disease based on serum Vegf, Il-8 and MMP-9
    Sci Rep, 2016;6(0):36065.
    Species: Human
    Sample Types: Serum
  52. A multiplex immunoassay for the non-invasive detection of bladder cancer.
    Authors: Shimizu Y, Furuya H, Bryant Greenwood P, Chan O, Dai Y, Thornquist M, Goodison S, Rosser C
    J Transl Med, 2016;14(1):31.
    Species: Human
    Sample Types: Urine
  53. Data on clinical significance of second trimester inflammatory biomarkers in the amniotic fluid in predicting preterm delivery
    Data Brief, 2016;9(0):47-50.
    Species: Human
    Sample Types: Amniotic Fluid
  54. Serum metalloproteinase 9 levels increase after generalized tonic-clonic seizures
    Authors: Iwona Kurkowska-
    Epilepsy Res., 2016;129(0):33-36.
    Species: Human
    Sample Types: Serum
  55. The C-terminus of IGFBP-5 suppresses tumor growth by inhibiting angiogenesis
    Sci Rep, 2016;6(0):39334.
    Species: Human
    Sample Types: Cell Culture Supernates
  56. Metallothionein-3 Increases Triple-Negative Breast Cancer Cell Invasiveness via Induction of Metalloproteinase Expression.
    Authors: Kmiecik A, Pula B, Suchanski J, Olbromski M, Gomulkiewicz A, Owczarek T, Kruczak A, Ambicka A, Rys J, Ugorski M, Podhorska-Okolow M, Dziegiel P
    PLoS ONE, 2015;10(5):e0124865.
    Species: Human
    Sample Types: Cell Culture Supernates
  57. Targeting the WASF3-CYFIP1 Complex Using Stapled Peptides Suppresses Cancer Cell Invasion.
    Authors: Teng Y, Bahassan A, Dong D, Hanold L, Ren X, Kennedy E, Cowell J
    Cancer Res, 2015;76(4):965-73.
    Species: Human
    Sample Types: Cell Culture Supernates
  58. Expression and Y435-phosphorylation of Abelson interactor 1 (Abi1) promotes tumour cell adhesion, extracellular matrix degradation and invasion by colorectal carcinoma cells.
    Authors: Steinestel K, Bruderlein S, Lennerz J, Steinestel J, Kraft K, Propper C, Meineke V, Moller P
    Mol Cancer, 2014;13(0):145.
    Species: Human
    Sample Types: Cell Culture Supernates
  59. Icariin ameliorates cigarette smoke induced inflammatory responses via suppression of NF-kappaB and modulation of GR in vivo and in vitro.
    Authors: Li L, Sun J, Xu C, Zhang H, Wu J, Liu B, Dong J
    PLoS ONE, 2014;9(8):e102345.
    Species: Human
    Sample Types: BALF
  60. Identification of a distinct glucocorticosteroid-insensitive pulmonary macrophage phenotype in patients with chronic obstructive pulmonary disease.
    Authors: Chana K, Fenwick P, Nicholson A, Barnes P, Donnelly L
    J Allergy Clin Immunol, 2014;133(1):207-16.e1-11.
    Species: Human
    Sample Types: Cell Culture Supernates
  61. Epigalloccatechin-3-gallate inhibits ocular neovascularization and vascular permeability in human retinal pigment epithelial and human retinal microvascular endothelial cells via suppression of MMP-9 and VEGF activation.
    Authors: Lee H, Jun J, Jung E, Koo B, Kim Y
    Molecules, 2014;19(8):12150-72.
    Species: Human
    Sample Types: Cell Culture Supernates
  62. Association between serum tissue inhibitor of matrix metalloproteinase-1 levels and mortality in patients with severe brain trauma injury.
    Authors: Lorente L, Martin M, Lopez P, Ramos L, Blanquer J, Caceres J, Sole-Violan J, Solera J, Cabrera J, Argueso M, Ortiz R, Mora M, Lubillo S, Jimenez A, Borreguero-Leon J, Gonzalez A, Orbe J, Rodriguez J, Paramo J
    PLoS ONE, 2014;9(4):e94370.
    Species: Human
    Sample Types: Serum
  63. The biochemical value of urinary metalloproteinases 3 and 9 in diagnosis and prognosis of bladder cancer in Egypt.
    Authors: El-Sharkawi, Fathia, El Sabah, Mahmoud, Hassan, Zeinab, Khaled, Hussein
    J Biomed Sci, 2014;21(0):72.
    Species: Human
    Sample Types: Urine
  64. KML001 inhibits cell proliferation and invasion in pancreatic cancer cells through suppression of NF-kappaB and VEGF-C.
    Authors: Yang M, Kim H, Lee K, Yang S, Lee J, Lee K, Rhee J
    Anticancer Res, 2014;34(7):3469-74.
    Species: Human
    Sample Types: Cell Culture Supernates
  65. Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte functions and dedifferentiation.
    Authors: Li S, Huang P, Yang A, Tarng D, Yang W, Lin C, Chen J, Schmid-Schonbein G, Lin S
    Kidney Int, 2014;86(2):358-69.
    Species: Human
    Sample Types: Urine
  66. Simultaneous multi-analyte urinary protein assay for bladder cancer detection.
    Authors: Rosser, Charles, Dai, Yunfeng, Miyake, Makito, Zhang, Ge, Goodison, Steve
    BMC Biotechnol, 2014;14(0):24.
    Species: Human
    Sample Types: Urine
  67. Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe?
    Authors: Naik, Pooja, Fofaria, Neel, Prasad, Shikha, Sajja, Ravi K, Weksler, Babette, Couraud, Pierre-O, Romero, Ignacio, Cucullo, Luca
    BMC Neurosci, 2014;15(0):51.
    Species: Human
    Sample Types: Cell Culture Supernates
  68. Role of serum VEGFA, TIMP2, MMP2 and MMP9 in monitoring response to adjuvant radiochemotherapy in patients with primary cervical cancer--results of a companion protocol of the randomized NOGGO-AGO phase III clinical trial.
    Authors: Braicu E, Gasimli K, Richter R, Nassir M, Kummel S, Blohmer J, Yalcinkaya I, Chekerov R, Ignat I, Ionescu A, Mentze M, Fotopoulou C, Pop C, Lichtenegger W, Sehouli J
    Anticancer Res, 2014;34(1):385-91.
    Species: Human
    Sample Types: Serum
  69. TLR ligands stimulation protects MSC from NK killing.
    Authors: Giuliani M, Bennaceur-Griscelli A, Nanbakhsh A, Oudrhiri N, Chouaib S, Azzarone B, Durrbach A, Lataillade J
    Stem Cells, 2014;32(1):290-300.
    Species: Human
    Sample Types: Cell Culture Supernates
  70. Antiproliferative, antiinvasive, and proapoptotic activity of folate receptor alpha-targeted liposomal doxorubicin in nonfunctional pituitary adenoma cells.
    Authors: Liu X, Ma S, Dai C, Cai F, Yao Y, Yang Y, Feng M, Deng K, Li G, Ma W, Xin B, Lian W, Xiang G, Zhang B, Wang R
    Endocrinology, 2013;154(4):1414-23.
    Species: Human
    Sample Types: Cell Culture Supernates
  71. Selective blockade of matrix metalloprotease-14 with a monoclonal antibody abrogates invasion, angiogenesis, and tumor growth in ovarian cancer.
    Authors: Kaimal R, Aljumaily R, Tressel S, Pradhan R, Covic L, Kuliopulos A, Zarwan C, Kim Y, Sharifi S, Agarwal A
    Cancer Res, 2013;73(8):2457-67.
    Species: Human
    Sample Types: Cell Culture Supernates
  72. IL-6-174 G > C and MMP-9-1562 C > T polymorphisms are associated with increased risk of deep vein thrombosis in cancer patients.
    Authors: Malaponte G, Polesel J, Candido S, Sambataro D, Bevelacqua V, Anzaldi M, Vella N, Fiore V, Militello L, Mazzarino M, Libra M, Signorelli S
    Cytokine, 2013;62(1):64-9.
    Species: Human
    Sample Types: Plasma
  73. Role of serum concentration of VEGFR1 and TIMP2 on clinical outcome in primary cervical cancer: results of a companion protocol of the randomized, NOGGO-AGO phase III adjuvant trial of simultaneous cisplatin-based radiochemotherapy vs. carboplatin and paclitaxel containing sequential radiotherapy.
    Authors: Braicu E, Fotopoulou C, Chekerov R, Richter R, Blohmer J, Kummel S, Stamatian F, Yalcinkaya I, Mentze M, Lichtenegger W, Sehouli J
    Cytokine, 2013;61(3):755-8.
    Species: Human
    Sample Types: Serum
  74. A multi-analyte assay for the non-invasive detection of bladder cancer.
    Authors: Goodison, Steve, Chang, Myron, Dai, Yunfeng, Urquidi, Virginia, Rosser, Charles
    PLoS ONE, 2012;7(10):e47469.
    Species: Human
    Sample Types: Urine
  75. Cerebrospinal Fluid Neopterin as Marker of the Meningo-Encephalitic Stage of Trypanosoma brucei gambiense Sleeping Sickness.
    Authors: Tiberti N, Hainard A, Lejon V, Courtioux B, Matovu E, Enyaru JC, Robin X, Turck N, Kristensson K, Ngoyi DM, Vatunga GM, Krishna S, Buscher P, Bisser S, Ndung'u JM, Sanchez JC
    PLoS ONE, 2012;7(7):e40909.
    Species: Human
    Sample Types: CSF
  76. Validation and quality control of ELISAs for the use with human saliva samples.
    Authors: Jaedicke KM, Taylor JJ, Preshaw PM
    J. Immunol. Methods, 2012;377(1):62-5.
    Species: Human
    Sample Types: Saliva
  77. Biomarkers of extracellular matrix metabolism (MMP-9 and TIMP-1) and risk of stroke, myocardial infarction, and cause-specific mortality: cohort study.
    Authors: Hansson J, Vasan RS, Arnlov J, Ingelsson E, Lind L, Larsson A, Michaelsson K, Sundstrom J
    PLoS ONE, 2011;6(1):e16185.
    Species: Human
    Sample Types: Serum
  78. Leptin administered in physiological or pharmacological doses does not regulate circulating angiogenesis factors in humans.
    Authors: Aronis KN, Diakopoulos KN, Fiorenza CG
    Diabetologia, 2011;54(9):2358-67.
    Species: Human
    Sample Types: Serum
  79. Increased levels of leukocyte-derived MMP-9 in patients with stable angina pectoris.
    Authors: Jonasson S, Lundberg A, Kalvegren H, Bergstrom I, Szymanowski A, Jonasson L
    PLoS ONE, 2011;6(4):e19340.
    Species: Human
    Sample Types: Serum
  80. Double-blind, randomized, multicentre, and active comparator controlled investigation of the effect of Pioglitazone, Metformin, and the combination of both on cardiovascular risk in patients with type 2 diabetes receiving stable basal insulin therapy: the PIOCOMB study.
    Authors: Hanefeld M, Pfutzner A, Forst T, Kleine I, Fuchs W
    Cardiovasc Diabetol, 2011;10(0):65.
    Species: Human
    Sample Types: Serum
  81. Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes.
    Authors: Verma S, Kumar M, Nerurkar VR
    J. Gen. Virol., 2011;92(0):507-15.
    Species: Human
    Sample Types: Cell Culture Supernates
  82. Characterization of innate immune signalling receptors in virus-induced acute asthma.
    Authors: Wood LG, Simpson JL, Wark PA, Powell H, Gibson PG
    Clin. Exp. Allergy, 2011;41(5):640-8.
    Species: Human
    Sample Types: Saliva
  83. Plasma haemoxygenase-1 in coronary artery disease. A comparison with angiogenin, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and vascular endothelial growth factor.
    Authors: Idriss NK, Lip GY, Balakrishnan B
    Thromb. Haemost., 2010;104(5):1029-37.
    Species: Human
    Sample Types: Plasma
  84. Broad regulation of matrix and adhesion molecules in THP-1 human macrophages by nitroglycerin.
    Authors: Krishnatry AS, Brazeau DA, Fung HL
    Nitric Oxide, 2010;22(1):11-7.
    Species: Human
    Sample Types: Cell Culture Supernates
  85. High matrix metalloproteinase production correlates with immune activation and leukocyte migration in leprosy reactional lesions.
    Authors: Teles RM, Teles RB, Amadeu TP, Moura DF, Mendonca-Lima L, Ferreira H, Santos IM, Nery JA, Sarno EN, Sampaio EP
    Infect. Immun., 2010;78(3):1012-21.
    Species: Human
    Sample Types: Serum
  86. Inhibition of EGFR pathway signaling and the metastatic potential of breast cancer cells by PA-MSHA mediated by type 1 fimbriae via a mannose-dependent manner.
    Authors: Liu ZB, Hou YF, Zhu J
    Oncogene, 2010;29(20):2996-3009.
    Species: Human
    Sample Types: Cell Culture Supernates
  87. Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with right ventricular structure and function: the MESA-RV Study.
    Authors: Kawut SM, Barr RG, Johnson WC
    Biomarkers, 2010;15(8):731-8.
    Species: Human
    Sample Types: Plasma
  88. In vitro secretion of matrix metalloprotease 9 is a prognostic marker in childhood acute lymphoblastic leukemia.
    Authors: Schneider P, Costa O, Legrand E
    Leuk. Res., 2010;34(1):24-31.
    Species: Human
    Sample Types: Cell Culture Supernates
  89. Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation.
    Authors: Reikvam H, Hatfield KJ, Oyan AM, Kalland KH, Kittang AO, Bruserud O
    Eur. J. Haematol., 2010;84(3):239-51.
    Species: Human
    Sample Types: Cell Culture Supernates
  90. Elevated serum matrix metalloproteinase-3 and -7 in H. pylori-related gastric cancer can be biomarkers correlating with a poor survival.
    Authors: Yeh YC, Sheu BS, Cheng HC, Wang YL, Yang HB, Wu JJ
    Dig. Dis. Sci., 2010;55(6):1649-57.
    Species: Human
    Sample Types: Serum
  91. Circulating matrix metalloproteinase-3 and metalloproteinase-9 and tissue Doppler measures of diastolic dysfunction to risk stratify patients with systolic heart failure.
    Authors: Buralli S, Dini FL, Ballo P, Conti U, Fontanive P, Duranti E, Metelli MR, Marzilli M, Taddei S
    Am. J. Cardiol., 2010;105(6):853-6.
    Species: Human
    Sample Types: Plasma
  92. The diagnostic value of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) determination in the sera of colorectal adenoma and cancer patients.
    Authors: Mroczko B, Groblewska M, Okulczyk B, Kedra B, Szmitkowski M
    Int J Colorectal Dis, 2010;25(10):1177-84.
    Species: Human
    Sample Types: Serum
  93. The effect of aspirin desensitization on novel biomarkers in aspirin-exacerbated respiratory diseases.
    Authors: Katial RK, Strand M, Prasertsuntarasai T, Leung R, Zheng W, Alam R
    J. Allergy Clin. Immunol., 2010;126(4):738-44.
    Species: Human
    Sample Types: Sputum
  94. Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression.
    Authors: Ghanim H, Sia CL, Upadhyay M, Korzeniewski K, Viswanathan P, Abuaysheh S, Mohanty P, Dandona P
    Am. J. Clin. Nutr., 2010;91(4):940-9.
    Species: Human
    Sample Types: Serum
  95. Abnormalities in metalloproteinase pathways and IGF-I axis: a link between birth weight, hypertension, and vascular damage in childhood.
    Authors: Sesso R, Franco MC
    Am. J. Hypertens., 2010;23(1):6-11.
    Species: Human
    Sample Types: Plasma
  96. Cerebrospinal fluid u-plasminogen activator and matrix metalloproteinase-9 levels in human eosinophilic meningitis associated with angiostrongyliasis.
    Authors: Sanpool O, Intapan PM, Thanchomnang T
    Cytokine, 2010;51(3):294-7.
    Species: Human
    Sample Types: CSF
  97. Mannitol challenge for assessment of airway responsiveness, airway inflammation and inflammatory phenotype in asthma.
    Authors: Wood LG, Powell H, Gibson PG
    Clin. Exp. Allergy, 2010;40(2):232-41.
    Species: Human
    Sample Types: Saliva
  98. Significant elevation of plasma matrix metalloproteinase-9 level and its ratio to matrix metalloproteinase-2 in patients with pelvic inflammatory disease.
    Authors: Wang PH, Tsai HT, Tee YT, Lin LY, Yang SF, Hsieh YS
    Fertil. Steril., 2009;92(5):1679-84.
    Species: Human
    Sample Types: Plasma
  99. A plant stanol yogurt drink alone or combined with a low-dose statin lowers serum triacylglycerol and non-HDL cholesterol in metabolic syndrome patients.
    Authors: Plat J, Brufau G, Dallinga-Thie GM, Dasselaar M, Mensink RP
    J. Nutr., 2009;139(6):1143-9.
    Species: Human
    Sample Types: Plasma
  100. Serum levels of matrix metalloproteinases -1,-2,-3 and -9 in thoracic aortic diseases and acute myocardial ischemia.
    Authors: Karapanagiotidis GT, Antonitsis P, Charokopos N, Foroulis CN, Anastasiadis K, Rouska E, Argiriadou H, Rammos K, Papakonstantinou C
    J Cardiothorac Surg, 2009;4(0):59.
    Species: Human
    Sample Types: Serum
  101. Immunomodulation by chronobiologically-based glucocorticoids treatment for multiple sclerosis relapses.
    Authors: Glass-Marmor L, Paperna T, Galboiz Y, Miller A
    J. Neuroimmunol., 2009;210(1):124-7.
    Species: Human
    Sample Types: Serum
  102. A urinary biomarker profile for children with HIV-associated renal diseases.
    Authors: Soler-Garcia AA, Rakhmanina NY, Mattison PC, Ray PE
    Kidney Int., 2009;76(2):207-14.
    Species: Human
    Sample Types: Urine
  103. Gender specific associations between matrix metalloproteinases and inflammatory markers in post myocardial infarction patients.
    Authors: Samnegard A, Hulthe J, Silveira A, Ericsson CG, Hamsten A, Eriksson P
    Atherosclerosis, 2009;202(2):550-6.
    Species: Human
    Sample Types: Serum
  104. Serum matrix metalloproteinases in adult CF patients: Relation to pulmonary exacerbation.
    Authors: Roderfeld M, Rath T, Schulz R, Seeger W, Tschuschner A, Graf J, Roeb E
    J. Cyst. Fibros., 2009;8(5):338-47.
    Species: Human
    Sample Types: Serum
  105. Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis.
    Authors: Lorente L, Martin MM, Labarta L, Diaz C, Sole-Violan J, Blanquer J, Orbe J, Rodriguez JA, Jimenez A, Borreguero-Leon JM, Belmonte F, Medina JC, Lliminana MC, Ferrer-Aguero JM, Ferreres J, Mora ML, Lubillo S, Sanchez M, Barrios Y, Sierra A, Paramo JA
    Crit Care, 2009;13(5):R158.
    Species: Human
    Sample Types: Serum
  106. Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.
    Authors: Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C
    Bone, 2009;44(6):1143-50.
    Species: Human
    Sample Types: Cell Culture Supernates
  107. Non-conventional markers of atherosclerosis before and after gastric banding surgery.
    Authors: Hanusch-Enserer U, Zorn G, Wojta J, Kopp CW, Prager R, Koenig W, Schillinger M, Roden M, Huber K
    Eur. Heart J., 2009;30(12):1516-24.
    Species: Human
    Sample Types: Plasma
  108. A TLR2 agonist in German cockroach frass activates MMP-9 release and is protective against allergic inflammation in mice.
    Authors: Page K, Ledford JR, Zhou P, Wills-Karp M
    J. Immunol., 2009;183(5):3400-8.
    Species: Human
    Sample Types: Cell Culture Supernates
  109. Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes.
    Authors: Rodriguez PC, Ernstoff MS, Hernandez C, Atkins M, Zabaleta J, Sierra R, Ochoa AC
    Cancer Res., 2009;69(4):1553-60.
    Species: Human
    Sample Types: Plasma
  110. Matrix metalloproteinase 9 is a mediator of epidermal growth factor-dependent e-cadherin loss in ovarian carcinoma cells.
    Authors: Cowden Dahl KD, Symowicz J, Ning Y, Gutierrez E, Fishman DA, Adley BP, Stack MS, Hudson LG
    Cancer Res., 2008;68(12):4606-13.
    Species: Human
    Sample Types: Ascites Fluid
  111. Lysyl oxidase activity in the ocular tissues and the role of LOX in proliferative diabetic retinopathy and rhegmatogenous retinal detachment.
    Authors: Coral K, Angayarkanni N, Madhavan J, Bharathselvi M, Ramakrishnan S, Nandi K, Rishi P, Kasinathan N, Krishnakumar S
    Invest. Ophthalmol. Vis. Sci., 2008;49(11):4746-52.
    Species: Human
    Sample Types: Vitreous Humor
  112. Activation of the osteopontin/matrix metalloproteinase-9 pathway correlates with prostate cancer progression.
    Authors: Castellano G, Malaponte G, Mazzarino MC, Figini M, Marchese F, Gangemi P, Travali S, Stivala F, Canevari S, Libra M
    Clin. Cancer Res., 2008;14(22):7470-80.
    Species: Human
    Sample Types: Plasma
  113. Urinary biomarkers predict brain tumor presence and response to therapy.
    Authors: Smith ER, Zurakowski D, Saad A, Scott RM, Moses MA
    Clin. Cancer Res., 2008;14(8):2378-86.
    Species: Human
    Sample Types: Urine
  114. The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells.
    Authors: Feng W, McCabe NP, Mahabeleshwar GH, Somanath PR, Phillips DR, Byzova TV
    J. Cell Biol., 2008;183(6):1145-57.
    Species: Mouse
    Sample Types: Cell Lysates
  115. Targeting a metalloprotease-PAR1 signaling system with cell-penetrating pepducins inhibits angiogenesis, ascites, and progression of ovarian cancer.
    Authors: Agarwal A, Covic L, Sevigny LM, Kaneider NC, Lazarides K, Azabdaftari G, Sharifi S, Kuliopulos A
    Mol. Cancer Ther., 2008;7(9):2746-57.
    Species: Human
    Sample Types: Ovarian Ascites Fluid
  116. Impact of acute exposure to tobacco smoke on gelatinases in the bronchoalveolar space.
    Authors: Glader P, Eldh B, Bozinovski S, Andelid K, Sjostrand M, Malmhall C, Anderson GP, Riise GC, Qvarfordt I, Linden A
    Eur. Respir. J., 2008;32(3):644-50.
    Species: Human
    Sample Types: BALF
  117. Gene transfer of matrix metalloproteinase-9 induces tumor regression of breast cancer in vivo.
    Authors: Bendrik C, Robertson J, Gauldie J, Dabrosin C
    Cancer Res., 2008;68(9):3405-12.
    Species: Human
    Sample Types: Tissue Homogenates
  118. Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure.
    Authors: Kissel CK, Lehmann R, Assmus B, Aicher A, Honold J, Fischer-Rasokat U, Heeschen C, Spyridopoulos I, Dimmeler S, Zeiher AM
    J. Am. Coll. Cardiol., 2007;49(24):2341-9.
    Species: Human
    Sample Types: Bone Marrow Fluid
  119. Actinobacillus actinomycetemcomitans lipopolysaccharide regulates matrix metalloproteinase, tissue inhibitors of matrix metalloproteinase, and plasminogen activator production by human gingival fibroblasts: a potential role in connective tissue destruction.
    Authors: Bodet C, Andrian E, Tanabe S, Grenier D
    J. Cell. Physiol., 2007;212(1):189-94.
    Species: Human
    Sample Types: Cell Culture Supernates
  120. Is metalloproteinase-7 specific for idiopathic pulmonary fibrosis?
    Authors: Huh JW, Kim DS, Oh YM, Shim TS, Lim CM, Lee SD, Koh Y, Kim WS, Kim WD, Kim KR
    Chest, 2007;133(5):1101-6.
    Species: Human
    Sample Types: BALF
  121. Plasma matrix metalloproteinase-9 level is better than serum matrix metalloproteinase-9 level to predict gastric cancer evolution.
    Authors: Wu CY, Wu MS, Chiang EP, Chen YJ, Chen CJ, Chi NH, Shih YT, Chen GH, Lin JT
    Clin. Cancer Res., 2007;13(7):2054-60.
    Species: Human
    Sample Types: Plasma
  122. Generation of endostatin by matrix metalloproteinase and cathepsin from human limbocorneal epithelial cells cultivated on amniotic membrane.
    Authors: Ma DH, Yao JY, Kuo MT, See LC, Lin KY, Chen SC, Chen JK, Chao AS, Wang SF, Lin KK
    Invest. Ophthalmol. Vis. Sci., 2007;48(2):644-51.
    Species: Human
    Sample Types: Cell Culture Supernates
  123. Clarithromycin targets neutrophilic airway inflammation in refractory asthma.
    Authors: Simpson JL, Powell H, Boyle MJ, Scott RJ, Gibson PG
    Am. J. Respir. Crit. Care Med., 2007;177(2):148-55.
    Species: Human
    Sample Types: Sputum
  124. Borrelia burgdorferi-induced monocyte chemoattractant protein-1 production in vivo and in vitro.
    Authors: Zhao Z, McCloud B, Fleming R, Klempner MS
    Biochem. Biophys. Res. Commun., 2007;358(2):528-33.
    Species: Human
    Sample Types: Tissue Homogenates
  125. Phase I clinical and pharmacodynamic evaluation of oral CI-1033 in patients with refractory cancer.
    Authors: Zinner RG, Nemunaitis J, Eiseman I, Shin HJ, Olson SC, Christensen J, Huang X, Lenehan PF, Donato NJ, Shin DM
    Clin. Cancer Res., 2007;13(10):3006-14.
    Species: Human
    Sample Types: Plasma
  126. Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma.
    Authors: Kleinman ME, Greives MR, Churgin SS, Blechman KM, Chang EI, Ceradini DJ, Tepper OM, Gurtner GC
    Arterioscler. Thromb. Vasc. Biol., 2007;27(12):2664-70.
    Species: Human
    Sample Types: Plasma
  127. Airway remodeling and lack of bronchodilator response in steroid-resistant asthma.
    Authors: Goleva E, Hauk PJ, Boguniewicz J, Martin RJ, Leung DY
    J. Allergy Clin. Immunol., 2007;120(5):1065-72.
    Species: Human
    Sample Types: BALF
  128. Matrix metalloprotease-9 dysregulation in lower airway secretions of cystic fibrosis patients.
    Authors: Gaggar A, Li Y, Weathington N, Winkler M, Kong M, Jackson P, Blalock JE, Clancy JP
    Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(1):L96-L104.
    Species: Human
    Sample Types: Sputum
  129. C-reactive protein induces endothelial cell apoptosis and matrix metalloproteinase-9 production in human mononuclear cells: Implications for the destabilization of atherosclerotic plaque.
    Authors: Nabata A, Kuroki M, Ueba H, Hashimoto S, Umemoto T, Wada H, Yasu T, Saito M, Momomura S, Kawakami M
    Atherosclerosis, 2007;196(1):129-35.
    Species: Human
    Sample Types: Cell Culture Supernates
  130. Urinary biomarkers in the early diagnosis of acute kidney injury.
    Authors: Han WK, Waikar SS, Johnson A, Betensky RA, Dent CL, Devarajan P, Bonventre JV
    Kidney Int., 2007;73(7):863-9.
    Species: Human
    Sample Types: Urine
  131. Pleiotrophic and anti-inflammatory effects of pioglitazone precede the metabolic activity in type 2 diabetic patients with coronary artery disease.
    Authors: Forst T, Karagiannis E, Lubben G, Hohberg C, Schondorf T, Dikta G, Drexler M, Morcos M, Danschel W, Borchert M, Pfutzner A
    Atherosclerosis, 2007;197(1):311-7.
    Species: Human
    Sample Types: Plasma
  132. Multiple biomarker use for detection of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome.
    Authors: Apple FS, Pearce LA, Chung A, Ler R, Murakami MM
    Clin. Chem., 2007;53(5):874-81.
    Species: Human
    Sample Types: Plasma
  133. ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging.
    Authors: Vishnubhotla R, Sun S, Huq J, Bulic M, Ramesh A, Guzman G, Cho M, Glover SC
    Lab. Invest., 2007;87(11):1149-58.
    Species: Human
    Sample Types: Cell Culture Supernates
  134. Pilot study of rosiglitazone therapy in women with breast cancer: effects of short-term therapy on tumor tissue and serum markers.
    Authors: Yee LD, Williams N, Wen P, Young DC, Lester J, Johnson MV, Farrar WB, Walker MJ, Povoski SP, Suster S, Eng C
    Clin. Cancer Res., 2007;13(1):246-52.
    Species: Human
    Sample Types: Serum
  135. Dental plaque, gingival inflammation, and elevated levels of interleukin-6 and cortisol in gingival crevicular fluid from women with stress-related depression and exhaustion.
    Authors: Johannsen A, Rylander G, Soder B, Asberg M
    J. Periodontol., 2006;77(8):1403-9.
    Species: Human
    Sample Types: Gingival Crevicular Fluid (GCF)
  136. Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice.
    Authors: Rofstad EK, Mathiesen B, Kindem K, Galappathi K
    Cancer Res., 2006;66(13):6699-707.
    Species: Human
    Sample Types: Cell Culture Supernates
  137. Role of platelet-derived growth factor and transforming growth factor beta1 the in the regulation of metalloproteinase expressions.
    Authors: Borrelli V, di Marzo L, Sapienza P, Colasanti M, Moroni E, Cavallaro A
    Surgery, 2006;140(3):454-63.
    Species: Human
    Sample Types: Cell Culture Supernates
  138. Humoral and cellular factors responsible for coronary collateral formation.
    Authors: Sherman JA, Hall A, Malenka DJ, De Muinck ED, Simons M
    Am. J. Cardiol., 2006;98(9):1194-7.
    Species: Human
    Sample Types: Plasma
  139. Effects of rosiglitazone alone and in combination with atorvastatin on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus.
    Authors: Chu CS, Lee KT, Lee MY, Su HM, Voon WC, Sheu SH, Lai WT
    Am. J. Cardiol., 2006;97(5):646-50.
    Species: Human
    Sample Types: Serum
  140. Serum levels of syndecan-1 in B-cell chronic lymphocytic leukemia: correlation with the extent of angiogenesis and disease-progression risk in early disease.
    Authors: Molica S, Vitelli G, Mirabelli R, Digiesu G, Giannarelli D, Cuneo A, Ribatti D, Vacca A
    Leuk. Lymphoma, 2006;47(6):1034-40.
    Species: Human
    Sample Types: Serum
  141. Ligation of the FcR gamma chain-associated human osteoclast-associated receptor enhances the proinflammatory responses of human monocytes and neutrophils.
    Authors: Merck E, Gaillard C, Scuiller M, Scapini P, Cassatella MA, Trinchieri G, Bates EE
    J. Immunol., 2006;176(5):3149-56.
    Species: Human
    Sample Types: Cell Culture Supernates
  142. Vascular endothelial growth factor modulates matrix metalloproteinase-9 expression in asthma.
    Authors: Lee KS, Min KH, Kim SR, Park SJ, Park HS, Jin GY, Lee YC
    Am. J. Respir. Crit. Care Med., 2006;174(2):161-70.
    Species: Human
    Sample Types: BALF
  143. Airway inflammation in iron ore miners exposed to dust and diesel exhaust.
    Authors: Adelroth E, Hedlund U, Blomberg A, Helleday R, Ledin MC, Levin JO, Pourazar J, Sandstrom T, Jarvholm B
    Eur. Respir. J., 2006;27(4):714-9.
    Species: Human
    Sample Types: Sputum
  144. Endurance training reduces circulating inflammatory markers in persons at risk of coronary events: impact on plaque stabilization?
    Authors: Niessner A, Richter B, Penka M, Steiner S, Strasser B, Ziegler S, Heeb-Elze E, Zorn G, Leitner-Heinschink A, Niessner C, Wojta J, Huber K
    Atherosclerosis, 2005;186(1):160-5.
    Species: Human
    Sample Types: Plasma
  145. Neutrophil-derived metalloproteinase-9 predicts healing quality after sinus surgery.
    Authors: Watelet JB, Demetter P, Claeys C, Van Cauwenberge P, Cuvelier C, Bachert C
    Laryngoscope, 2005;115(1):56-61.
    Species: Human
    Sample Types: Nasal Fluid
  146. Induced sputum matrix metalloproteinase-9 correlates with lung function and airway inflammation in children with cystic fibrosis.
    Authors: Sagel SD, Kapsner RK, Osberg I
    Pediatr. Pulmonol., 2005;39(3):224-32.
    Species: Human
    Sample Types: Sputum
  147. Aberrant neutrophil reactions in periodontitis.
    Authors: Figueredo CM, Fischer RG, Gustafsson A
    J. Periodontol., 2005;76(6):951-5.
    Species: Human
    Sample Types: Gingival Crevicular Fluid (GCF)
  148. A comparison of airway and serum matrix metalloproteinase-9 activity among normal subjects, asthmatic patients, and patients with asthmatic mucus hypersecretion.
    Authors: Ko FW, Diba C, Roth M, McKay K, Johnson PR, Salome C, King GG
    Chest, 2005;127(6):1919-27.
    Species: Human
    Sample Types: Serum
  149. Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma.
    Authors: Simpson JL, Scott RJ, Boyle MJ, Gibson PG
    Am. J. Respir. Crit. Care Med., 2005;172(5):559-65.
    Species: Human
    Sample Types: Sputum
  150. Plasma storage at -80 degrees C does not protect matrix metalloproteinase-9 from degradation.
    Authors: Rouy D, Ernens I, Jeanty C, Wagner DR
    Anal. Biochem., 2005;338(2):294-8.
    Species: Human
    Sample Types: Plasma
  151. Determination of the serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in patients with either advanced small-cell lung cancer or non-small-cell lung cancer prior to treatment.
    Authors: Jumper C, Cobos E, Lox C
    Respir Med, 2004;98(2):173-7.
    Species: Human
    Sample Types: Serum
  152. CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion.
    Authors: Singh S, Singh UP, Grizzle WE, Lillard JW
    Lab. Invest., 2004;84(12):1666-76.
    Species: Human
    Sample Types: Cell Culture Supernates
  153. Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells.
    Authors: Li DQ, Chen Z, Song XJ, Luo L, Pflugfelder SC
    Invest. Ophthalmol. Vis. Sci., 2004;45(12):4302-11.
    Species: Human
    Sample Types: Cell Culture Supernates
  154. Intrafollicular expression of matrix metalloproteinases and their inhibitors in normally ovulating women compared with patients undergoing in vitro fertilization treatment.
    Authors: D&amp;amp;apos;Ascenzo S, Giusti I, Millimaggi D, Marci R, Tatone C, Cardigno Colonna R, Moscarini M, Pavan A, Dolo V, Caserta D
    Eur. J. Endocrinol., 2004;151(1):87-91.
    Species: Human
    Sample Types: Follicular Fluid
  155. Matrix metalloprotenase-9 in acute pyelonephritis.
    Authors: Laudanski P, Reduta T
    Pediatr. Res., 2004;55(2):357; author r.
    Species: Human
    Sample Types: Urine
  156. Gonadotropin and steroid regulation of matrix metalloproteinases and their endogenous tissue inhibitors in the developed corpus luteum of the rhesus monkey during the menstrual cycle.
    Authors: Young KA, Stouffer RL
    Biol. Reprod., 2003;70(1):244-52.
    Species: Primate
    Sample Types: Tissue Homogenates
  157. Matrix metalloproteinases production in malignant pleural effusions after talc pleurodesis.
    Authors: D&amp;amp;apos;Agostino P
    Clin. Exp. Immunol., 2003;134(1):138-42.
    Species: Human
    Sample Types: Pleural Effusion
  158. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in sera and tissue of patients with Dupuytren's disease.
    Authors: Ulrich D, Hrynyschyn K, Pallua N
    Plast. Reconstr. Surg., 2003;112(5):1279-86.
    Species: Human
    Sample Types: Serum
  159. Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma.
    Authors: Doubrovina ES, Doubrovin MM, Vider E, Sisson RB, O&amp;amp;apos;Reilly RJ, Dupont B, Vyas YM
    J. Immunol., 2003;171(12):6891-9.
    Species: Human
    Sample Types: Serum
  160. Antidiabetic PPAR gamma-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary artery disease.
    Authors: Marx N, Froehlich J, Siam L, Ittner J, Wierse G, Schmidt A, Scharnagl H, Hombach V, Koenig W
    Arterioscler. Thromb. Vasc. Biol., 2003;23(2):283-8.
    Species: Human
    Sample Types: Serum
  161. Anti-inflammatory cytokine profile in acute coronary syndromes: behavior of interleukin-10 in association with serum metalloproteinases and proinflammatory cytokines.
    Authors: Tziakas DN, Chalikias GK, Hatzinikolaou HI, Parissis JT, Papadopoulos ED, Trypsianis GA, Papadopoulou E, Tentes IK, Karas SM, Hatseras DI
    Int. J. Cardiol., 2003;92(2):169-75.
    Species: Human
    Sample Types: Serum
  162. Matrix metalloproteinase-9, but not tissue inhibitor of matrix metalloproteinase-1, increases in the sputum from allergic asthmatic patients after allergen challenge.
    Authors: Cataldo DD, Bettiol J, Noel A, Bartsch P, Foidart JM, Louis R
    Chest, 2002;122(5):1553-9.
    Species: Human
    Sample Types: Sputum
  163. Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1: a possible role in the pathogenesis of endometriosis.
    Authors: Szamatowicz J, Laudanski P, Tomaszewska I
    Hum. Reprod., 2002;17(2):284-8.
    Species: Human
    Sample Types: Peritoneal Fluid
  164. Induced sputum-retrieved matrix metalloproteinase 9 and tissue metalloproteinase inhibitor 1 in granulomatous diseases.
    Authors: Fireman E, Kraiem Z, Sade O, Greif J, Fireman Z
    Clin. Exp. Immunol., 2002;130(2):331-7.
    Species: Human
    Sample Types: Saliva

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Human MMP-9 Quantikine ELISA Kit
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Human MMP-9 Quantikine ELISA Kit
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Application: Sample Tested: Serum

Human MMP-9 Quantikine ELISA Kit
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Application: Sample Tested: Cell culture supernatant