Detection of Integrin alpha 6/CD49f in Human Blood Lymphocytes by Flow Cytometry.
Human peripheral blood lymphocytes were stained with Rat Anti-Human/Mouse/Bovine Integrin alpha 6/CD49f APC‑conjugated Monoclonal Antibody (Catalog # FAB13501A, filled histogram) or isotype control antibody (Catalog # IC006A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Detection of Integrin alpha 6/CD49f in Mouse Splenocytes by Flow Cytometry.
Mouse splenocytes were stained with Rat Anti-Human/Mouse/Bovine Integrin alpha 6/CD49f APC‑conjugated Monoclonal Antibody (Catalog # FAB13501A) and Rat Anti-Mouse CD3 PE‑conjugated Monoclonal Antibody (Catalog # FAB4841P). Quadrant markers were set based on control antibody staining (Catalog # IC006A). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
12 months from date of receipt, 2 to 8 °C as supplied.
Background: Integrin alpha 6/CD49f
Integrin alpha 6 (also VLA-6, CD49F and ITA6) is a 130-150 kDa member of the Integrin alpha chain family of molecules. Mature Integrin alpha 6 is a 1107 amino acid (aa) type I transmembrane glycoprotein that contains a 1027 aa extracellular region and a 93 aa cytoplasmic tail. The ECD is cleaved to generate a disulfide-linked dimer that shows a 125 kDa heavy chain (aa 24-938), and a 30-31 kDa membrane-bound light chain (aa 942-1130). Integrin alpha 6 forms a nondisulfide-linked heterodimeric complex with both integrin beta 1 and beta 4. Each complex serves as a receptor for laminin.
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