RCOR1 (REST [RE-1 silencing transcription factor] CORepressor 1; also CoREST) is a 64‑66 kDa member of the CoREST family of proteins. It is a nuclear protein that is ubiquitously expressed. RCOR1 serves as a molecular bridge, linking REST with Sin3, HDAC, LSD1, histone H3 K9 methyltransferases, and MeCP2. This creates a complex that represses the expression of neuron‑specific genes in nonneuronal cells, principally by coordinating the demethylation of Lys4 in histone H3. Human RCOR1 is 482 amino acids (aa) in length. It contains one ELM2 domain (aa 102‑157) that interacts with HDAC, and two SANT sequences (aa 187‑238 and 378‑429) that bind DNA tandem repeats. There are three potential RCOR1 splice variants. One contains a four aa substitution for aa 296‑482, a second shows an alternative start site 3 aa upstream of the standard site, while a third shares the same upstream start site accompanied by a 15 aa substitution for aa 471‑482. Over aa 394‑482, human RCOR1 shares 93% aa identity with mouse RCOR1.
Human/Mouse RCOR1/CoREST Alexa Fluor™ Plus 594‑conjugated Antibody
R&D Systems | Catalog # AF6047AFP594
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Applications for Human/Mouse RCOR1/CoREST Alexa Fluor™ Plus 594‑conjugated Antibody
Western Blot
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Background: RCOR1/CoREST
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Product Specific Notices for Human/Mouse RCOR1/CoREST Alexa Fluor™ Plus 594‑conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
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