Human/Mouse RPTOR Alexa Fluor® 488-conjugated Antibody Summary
Accession # Q8N122
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
RPTOR (Raptor) is a 150 kDa component of the cytosolic mammalian target of Rapamycin complex 1 (mTORC1) which also contains mTOR and GBL proteins. mTORC1 plays a dominant role in cell cycle regulation in response to metabolic conditions. The interaction of RPTOR with the kinase mTOR is stabilized under conditions of nutrient deprivation and energy stress, leading to inhibition of mTOR and cell cycle arrest. RPTOR contains multiple Ser and Thr residues whose phosphorylation regulates the activation status of mTOR. RPTOR is critical for the response of skeletal muscle and adipose tissue to insulin. It contains three RNC blocks (aa 48-511), three HEAT repeats (aa 550-667), and seven C-terminal WD40 domains (aa 1020-1335). Within aa 77-230, human RPTOR shares 100% aa sequence identity with mouse and rat RPTOR.
Citation for Human/Mouse RPTOR Alexa Fluor® 488-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function
Authors: F Wang, M Meng, B Mo, Y Yang, Y Ji, P Huang, W Lai, X Pan, T You, H Luo, X Guan, Y Deng, S Yuan, J Chu, M Namaka, T Hughes, L Ye, J Yu, X Li, Y Deng
Nat Commun, 2018;9(1):4874.
Sample Types: Whole Cells
Applications: Flow Cytometry
No product specific FAQs exist for this product, however you mayView all Antibody FAQs
Reviews for Human/Mouse RPTOR Alexa Fluor® 488-conjugated Antibody
There are currently no reviews for this product. Be the first to review Human/Mouse RPTOR Alexa Fluor® 488-conjugated Antibody and earn rewards!
Have you used Human/Mouse RPTOR Alexa Fluor® 488-conjugated Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image