Home / SOCS-3 / Human/Mouse SOCS-3 Alexa Fluor® 750-conjugated Antibody

Human/Mouse SOCS-3 Alexa Fluor® 750-conjugated Antibody

Catalog #: FAB5696S Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
FAB5696S-100UG

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Human/Mouse SOCS-3 Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity
Human, Mouse
Specificity
Detects human or mouse SOCS-3 in Western blots.
Source
Monoclonal Mouse IgG2b Clone # 516919
Purification
Protein A or G purified
Immunogen
E. coli-derived recombinant human SOCS-3
Met1-Leu225
Accession # O14543
Formulation
Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide
Label
Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration
Sample
Western Blot
Optimal dilution of this antibody should be experimentally determined.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: SOCS-3

Suppressor of cytokine signaling 3 (SOCS-3), also known as CIS3, is a widely expressed 30 kDa protein that inhibits signal transduction induced by multiple cytokines including Erythropoietin, IL-6, LIF, Oncostatin M, and Leptin. It binds downstream signaling molecules such as JAK kinases and targets them for ubiquitin-mediated degradation, essential in a negative feedback control loop. Human SOCS-3 shares 96% aa sequence identity with mouse and rat SOCS-3.

Long Name
Suppressor Of Cytokine Signaling 3
Entrez Gene IDs
9021 (Human); 12702 (Mouse); 89829 (Rat)
Alternate Names
ATOD4; CIS3; CIS3CIS-3; Cish3; cytokine-induced SH2 protein 3; Cytokine-inducible SH2 protein 3; SOCS3; SOCS-3; SOCS-3STAT-induced STAT inhibitor 3; SSI-3; SSI-3ATOD4; SSI3MGC71791; suppressor of cytokine signaling 3

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