Human/Mouse STAT4 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB5287R Datasheet / COA / SDS

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FAB5287R-100UG

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Human/Mouse STAT4 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human, Mouse

Specificity

Detects endogenous human STAT4 in Western blots.

Source

Monoclonal Mouse IgG2a Clone # 513710

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human STAT4
Leu83-Lys162
Accession # Q14765

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: STAT4

Signal transduction and activator of transcription 4 (STAT4) is a 86 kDa member of the Jak/STAT signal transduction pathway. Human STAT4 is 748 amino acids (aa) in length. STAT4 mediates cytokine signaling by acting as a signal transducer in the cytoplasm and, upon phosphorylation, homo- or heterodimerizes with other STAT proteins, which then translocate to the nucleus and activate transcription of specific genes. STAT4 contains a SH2 domain (aa 569‑664) and a Jak1 phophorylation site at Y693. STAT4 is involved in mediating IL‑12 response in lymphocytes and regulating T helper cell differentiation, and STAT4 variants are found in patients with systemic lupus erythematosus.

Long Name

Signal Transducer and Activator of Transcription 4

Entrez Gene IDs

6775 (Human); 20849 (Mouse)

Alternate Names

signal transducer and activator of transcription 4; SLEB11; STAT4