Th2 Differentiation Pathway

Click on one of the boxes below to see the processes that promote Th2 differentiation and the transcription factors, secreted molecules, and some of the cell surface markers that distinguish a differentiated Th2 cell from the other T helper cell subtypes.

Antigen Presenting Cell
Antigen Presenting Cell
B7
B7
MHC-II
MHC-II
OX40 Ligand
OX40 Ligand
Naïve CD4+ T Cell
Naïve CD4+ T Cell
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CD28
CD28
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TCR-CD3
TCR-CD3
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OX40
OX40
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CD4
CD4
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IL-2
IL-2
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CD25/IL-2 R alpha
CD25/IL-2 R alpha
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IL-2 R beta
IL-2 R beta
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Common gamma Chain
Common gamma Chain
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Jak1
Jak1
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Jak2
Jak2
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Jak3
Jak3
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STAT5a
STAT5a
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STAT5a Dimer
STAT5a Dimer
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STAT5a Dimer
STAT5a Dimer
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IL-4
IL-4
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IL-4 R alpha
IL-4 R alpha
Common gamma Chain
Common gamma Chain
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Jak1
Jak1
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Jak3
Jak3
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STAT6
STAT6
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STAT6 Dimer
STAT6 Dimer
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STAT6 Dimer
STAT6 Dimer
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STAT5a
STAT5a
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Jagged
Jagged
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Notch
Notch
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MAML
MAML
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CSL/RBPj
CSL/RBPj
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IL-4
IL-4
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GATA-3
GATA-3
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IL-4 R alpha
IL-4 R alpha
Committed Th2 Cell
Committed Th2 Cell
IL-2
IL-2
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CD25/IL-2 R alpha
CD25/IL-2 R alpha
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IL-2 R beta
IL-2 R beta
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Common gamma Chain
Common gamma Chain
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Jak1
Jak1
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Jak2
Jak2
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Jak3
Jak3
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STAT5a
STAT5a
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STAT5a Dimer
STAT5a Dimer
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STAT5a Dimer
STAT5a Dimer
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IL-4
IL-4
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IL-4 R alpha
IL-4 R alpha
Common gamma Chain
Common gamma Chain
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Jak1
Jak1
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Jak3
Jak3
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STAT6
STAT6
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STAT6 Dimer
STAT6 Dimer
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STAT6 Dimer
STAT6 Dimer
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STAT5a
STAT5a
Jagged
Jagged
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Notch
Notch
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NICD
NICD
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NICD
NICD
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MAML
MAML
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CSL/RBPj
CSL/RBPj
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GATA-3
GATA-3
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IL-4 R alpha
IL-4 R alpha
IL-4 R alpha
IL-4 R alpha
IL-4
IL-4
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IL-5
IL-5
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IL-13
IL-13
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IL-33
IL-33
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c-Maf
c-Maf
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GFI-1
GFI-1
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GATA-3
GATA-3
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GATA-3
GATA-3
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DEC2
DEC2
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ST2
ST2
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IL-4
IL-4
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IL-5
IL-5
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IL-10
IL-10
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IL-13
IL-13
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IFN-gamma
IFN-gamma
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IL-12 R beta 2
IL-12 R beta 2
STAT4
STAT4
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FoxP3
FoxP3
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IL-4
IL-4
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IL-5
IL-5
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IL-10
IL-10
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IL-13
IL-13
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IL-33
IL-33
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Differentiated Th2 Cell
Differentiated Th2 Cell
IL-2
IL-2
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CD25/IL-2 R alpha
CD25/IL-2 R alpha
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IL-2 R beta
IL-2 R beta
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Common gamma Chain
Common gamma Chain
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Jak1
Jak1
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Jak2
Jak2
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Jak3
Jak3
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STAT5a
STAT5a
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STAT5a Dimer
STAT5a Dimer
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STAT5a Dimer
STAT5a Dimer
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IL-4
IL-4
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IL-4 R alpha
IL-4 R alpha
Common gamma Chain
Common gamma Chain
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Jak1
Jak1
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Jak3
Jak3
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STAT6
STAT6
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STAT6 Dimer
STAT6 Dimer
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STAT6 Dimer
STAT6 Dimer
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STAT5a
STAT5a
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Jagged
Jagged
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Notch
Notch
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NICD
NICD
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NICD
NICD
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MAML
MAML
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CSL/RBPj
CSL/RBPj
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GATA-3
GATA-3
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IL-4 R alpha
IL-4 R alpha
IL-4
IL-4
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IL-5
IL-5
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IL-13
IL-13
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IL-33
IL-33
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IL-4 R alpha
IL-4 R alpha
c-Maf
c-Maf
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GFI-1
GFI-1
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GATA-3
GATA-3
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GATA-3
GATA-3
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DEC2
DEC2
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ST2
ST2
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IL-4
IL-4
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IL-5
IL-5
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IL-10
IL-10
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IL-13
IL-13
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IFN-gamma
IFN-gamma
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IL-12 R beta 2
IL-12 R beta 2
STAT4
STAT4
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FoxP3
FoxP3
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IL-4
IL-4
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IL-5
IL-5
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IL-9
IL-9
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IL-10
IL-10
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IL-13
IL-13
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IL-17E
IL-17E
IL-31
IL-31
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IL-33
IL-33
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CCL11
CCL11
CCL17
CCL17
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CCL22
CCL22
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Amphiregulin
Amphiregulin
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TSLP R
TSLP R
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ST2/IL-1 R4
ST2/IL-1 R4
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IL-17 RB
IL-17 RB
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Overview of Th2 Differentiation

CD4+ T cells play a central role in the adaptive immune response. They are critically involved in recruiting and activating other immune cells, dampening ongoing immune responses, and maintaining immunologic memory. Following T cell receptor activation and co-stimulation by antigen-presenting cells (APC), naïve CD4+ T cells differentiate into one of several lineages of T helper cell subtypes. These subsets express characteristic combinations of transcription factors, cell surface proteins, and secreted molecules. T helper type 2 (Th2) cells provide host protection against intestinal helminths and extracellular bacteria in addition to support for B cell-dependent humoral responses. Pathological Th2 cell activity is a hallmark of allergic inflammation and asthma.

To learn more, please visit our Th2 Cells Research Area.

Th2 Differentiation Pathway background image 1Th2 Differentiation Pathway background image 2Th2 Differentiation Pathway background image 3Th2 Differentiation Pathway background image 4