Click on one of the boxes below to see the processes that promote Th2 differentiation and the transcription factors, secreted molecules, and some of the cell surface markers that distinguish a differentiated Th2 cell from the other T helper cell subtypes.
CD4+ T cells play a central role in the adaptive immune response. They are critically involved in recruiting and activating other immune cells, dampening ongoing immune responses, and maintaining immunologic memory. Following T cell receptor activation and co-stimulation by antigen-presenting cells (APC), naïve CD4+ T cells differentiate into one of several lineages of T helper cell subtypes. These subsets express characteristic combinations of transcription factors, cell surface proteins, and secreted molecules. T helper type 2 (Th2) cells provide host protection against intestinal helminths and extracellular bacteria in addition to support for B cell-dependent humoral responses. Pathological Th2 cell activity is a hallmark of allergic inflammation and asthma.