Th2 Differentiation Pathway

CD4⁺ T cells play a central role in the adaptive immune response. They are critically involved in recruiting and activating other immune cells, dampening ongoing immune responses, and maintaining immunologic memory. Following T cell receptor activation and co-stimulation by antigen-presenting cells (APC), naïve CD4⁺ T cells differentiate into one of several lineages of T helper cell subtypes. These subsets express characteristic combinations of transcription factors, cell surface proteins, and secreted molecules. T helper type 2 (Th2) cells provide host protection against intestinal helminths and extracellular bacteria in addition to support for B cell-dependent humoral responses. Pathological Th2 cell activity is a hallmark of allergic inflammation and asthma.

To learn more, please visit our Th2 Cells Research Area.