Human/Mouse Tec Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Tec

The tyrosine protein kinase Tec is an approximately 70 kDa member of the protein kinase superfamily, tyrosine protein family, and Tec subfamily.  Human Tec is 631 amino acids (aa) in length.  Amino acid residues 4-111 constitute a Tec pleckstrin homology (PH) domain, and aa 113-149 make up a Btk-type zinc finger.  Residues 179-239 form a Src homology 3 (SH3) domain, and aa 247-345 make up a Src homology 2 (SH2) domain.  The region involving positions 365-620 constitutes the catalytic domain of the protein tyrosine kinases.  Human Tec shares 94% aa sequence identity with mouse Tec.  Human Tec is expressed in hematopoietic cell lines including B-cell, T-cell, and myeloid lineages.

Product Datasheets

Related Research Areas

• Intracellular Kinases
• Search Kinases and Phosphatases