Human NKG2C/CD159c PE-conjugated Antibody

Catalog # Availability Size / Price Qty
FAB138P-025
FAB138P-100
Best Seller
Detection of NKG2C/CD159c in Human PBMCs by Flow Cytometry.
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Citations (68)
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Human NKG2C/CD159c PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human NKG2C/CD159c heterodimer with CD94 in flow cytometry. It does not cross-react with the human NKG2A/CD94 heterodimer or with the human CD94 homodimer.
Source
Monoclonal Mouse IgG1 Clone # 134591
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
BaF3 mouse pro-B cell line transfected with human NKG2C/CD159c and CD94
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of NKG2C/CD159c antibody in Human PBMCs antibody by Flow Cytometry. View Larger

Detection of NKG2C/CD159c in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human NCAM-1/CD56 APC-conjugated Monoclonal Antibody (Catalog # FAB2408A) and either (A) Mouse Anti-Human NKG2C/CD159c PE-conjugated Monoclonal Antibody (Catalog # FAB138P) or (B) Mouse IgG1Phycoerythrin Isotype Control (Catalog # IC002P). View our protocol for Staining Membrane-associated Proteins.

Flow Cytometry Detection of Human NKG2C/CD159c/KLRC2 by Flow Cytometry View Larger

Detection of Human NKG2C/CD159c/KLRC2 by Flow Cytometry Enhancement of cytokine‐driven IFN‐ gamma production within CD56bright, CD56dimNKG2C−CD57− and CD56dimNKG2C+CD57− NK cells after vaccination. (A) Frequencies of IFN‐ gamma producing NK cells after HCC stimulation of PBMC at baseline (0) and up to 24 weeks post TIV vaccination. (B) Gating strategy showing CD57 and NKG2C‐defined subsets. (C, D) Subset distribution for NK cell IFN‐ gamma production after HCC stimulation of pre (0 weeks) and post‐vaccination (4, 12, 24 weeks) samples from subjects receiving (C) TIV and (D) DTPiP. Dots represent the frequency of IFN‐ gamma + NK cells for each subject and horizontal lines represent median frequency for each group. Statistical analysis was performed on paired samples using Wilcoxon signed‐rank test, *p < 0.05, **p < 0.01. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/28383105), licensed under a CC-BY license. Not internally tested by R&D Systems.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: NKG2C/CD159c

Human NKG2C (NK cell Group 2 isoform C; Killer cell lectin-like receptor subfamily C, member 2) is a member of the C-type lectin-like superfamily of proteins. Natural killer (NK) receptors are expressed in both NK cells and cytotoxic CD8+ T cells and have both activating and inhibitory members (1-3). Regulation of the balance between the activating and inhibitory receptors is important and lack of such regulation has been implicated in autoimmunity (4). The NKG2 family includes seven receptors: NKG2A, -B, -C, -D, -E, -F, and -H, which is the longer isoform of NKG2E. Except for NKG2D and NKG2F, the NKG2 family members form heterodimers with CD94 (5, 6). NKG2C interacts with the adapter molecule DAP12 and acts as activating receptor when heterodimerized with CD94 (7). Human NKG2C is synthesized as a 231 amino acid (aa) protein that includes a 70 aa cytoplasmic domain, a 23 aa transmembrane segment, and a 138 aa extracellular domain (ECD). Within the ECD, human NKG2C shares 40% sequence identity with mouse NKG2C. NKG2C-CD94 heterodimers bind to the widely expressed nonclassical MHC-I molecule, HLA-E (Qa-1b in mouse), which presents a peptide derived from the signal peptide of classical MHC-I molecules (8, 9). Triggering the NKG2C-CD94 complex may activate the cytolytic activity and cytokine production of NK and CD8+ T cells (8, 10). Human cytomegalovirus (HCMV) infection promotes the differentiation and expansion of NKG2C+ NK cell subsets, possibly involving a cognate interaction of CD94/NKG2C with ligand(s) displayed by HCMV‑infected cells (11, 12).

References
  1. Orbelyan, G.A. et al. (2014) J. Immunol. 193:610.
  2. Tassi I. et al. (2006) Immnunol Rev. 214:92.
  3. Lanier, L.L. (2008) Nat. Immunol. 9:495.
  4. Schleinitz, N. et al. (2010) Immunology. 174:2878.
  5. Lopez-Botet, M. et al. (2000) Hum. Immunol. 61:7.
  6. Braud, V.M. et al. (1998) Nature. 391:795.
  7. Lanier, L.L. (1998) Immunity 8:693.
  8. Vance, R.E. et al. (1999) J Exp Med 190:1801.
  9. Kaiser B.K. et al. (2005) J Immunol 174:2878.
  10. Bellón T. et al. (1999) J Immunol 162:3996.
  11. Pupuleku A. et al. (2017) Front Immunol. 8:1317.
  12. Hammer Q. et al. (2018) Nat Immunol. 19:453.
Long Name
Natural Killer G2C
Entrez Gene IDs
3822 (Human); 16642 (Mouse)
Alternate Names
CD159 antigen-like family member C; CD159c antigen; CD159c; killer cell lectin-like receptor subfamily C, member 2; KLRC2; MGC138244; NK cell receptor C; NKG2-C type II integral membrane protein; NKG2C; NKG2-C; NKG2CNKG2-C-activating NK receptor

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Citations for Human NKG2C/CD159c PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

68 Citations: Showing 1 - 10
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  1. Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function
    Authors: Conor N. Gruber, Jorg J.A. Calis, Sofija Buta, Gilad Evrony, Jerome C. Martin, Skyler A. Uhl et al.
    Immunity
  2. Tumor-Targeting Anti-CD20 Antibodies Mediate In Vitro Expansion of Memory Natural Killer Cells: Impact of CD16 Affinity Ligation Conditions and In Vivo Priming
    Authors: Cristina Capuano, Simone Battella, Chiara Pighi, Lavinia Franchitti, Ombretta Turriziani, Stefania Morrone et al.
    Frontiers in Immunology
  3. Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development
    Authors: Carissa Dege, Katherine H. Fegan, J. Philip Creamer, Melissa M. Berrien-Elliott, Stephanie A. Luff, Darren Kim et al.
    Developmental Cell
  4. Adaptive and Innate Cytotoxic Effectors in Chronic Lymphocytic Leukaemia (CLL) Subjects with Stable Disease
    Authors: Rubino, V;Carriero, F;Palatucci, AT;Giovazzino, A;Leone, S;Nicolella, V;Calabrò, M;Montanaro, R;Brancaleone, V;Pane, F;Chiurazzi, F;Ruggiero, G;Terrazzano, G;
    International journal of molecular sciences
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. PGE2 expression by HPV6/11-induced respiratory papillomas blocks NK cell activation in patients with recurrent respiratory papillomatosis
    Authors: M Israr, F Lam, J DeVoti, EM Mace, C Papayannak, A Abramson, BM Steinberg, VR Bonagura
    European Journal of Immunology, 2023-01-31;0(0):e2250036.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  6. The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency
    Authors: S Wahlen, F Matthijsse, W Van Loocke, S Taveirne, L Kiekens, E Persyn, E Van Ammel, Z De Vos, S De Munter, P Matthys, F Van Nieuwe, T Taghon, B Vandekerck, P Van Vlierb, G Leclercq
    Elife, 2022-07-06;11(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  7. Increased Susceptibility of the CD57- NK Cells Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral Transduction and the Relationships with Proliferative Potential, Activation Degree, and Death Induction Response
    Authors: AI Palamarchu, NA Alekseeva, MA Streltsova, MO Ustiuzhani, PA Kobyzeva, SA Kust, MV Grechikhin, AA Boyko, OA Shustova, AM Sapozhniko, EI Kovalenko
    International Journal of Molecular Sciences, 2021-12-11;22(24):.
    Species: Human
    Sample Types: Transduced Whole Cells, Whole Cells
    Applications: Flow Cytometry
  8. An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults
    Authors: VA Vieira, E Adland, DFG Malone, MP Martin, A Groll, MA Ansari, MC Garcia-Gue, MC Puertas, M Muenchhoff, CF Guash, C Brander, J Martinez-P, A Bamford, G Tudor-Will, T Ndung'u, BD Walker, V Ramsuran, J Frater, P Jooste, D Peppa, M Carrington, PJR Goulder
    PloS Pathogens, 2021-11-18;17(11):e1010090.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  9. Characterization of Adaptive-like gammadelta T Cells in Ugandan Infants during Primary Cytomegalovirus Infection
    Authors: J Tuengel, S Ranchal, A Maslova, G Aulakh, M Papadopoul, S Drissler, B Cai, C Mohsenzade, H Soudeyns, S Mostafavi, P van den El, D Vermijlen, L Cook, S Gantt
    Viruses, 2021-10-03;13(10):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  10. Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy
    Authors: KV Woan, H Kim, R Bjordahl, ZB Davis, S Gaidarova, J Goulding, B Hancock, S Mahmood, R Abujarour, H Wang, K Tuininga, B Zhang, CY Wu, B Kodal, M Khaw, L Bendzick, P Rogers, MQ Ge, G Bonello, M Meza, M Felices, J Huffman, T Dailey, TT Lee, B Walcheck, KJ Malmberg, BR Blazar, YT Bryceson, B Valamehr, JS Miller, F Cichocki
    Cell Stem Cell, 2021-09-14;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  11. Telomerase Reverse Transcriptase Increases Proliferation and Lifespan of Human NK Cells without Immortalization
    Authors: MA Streltsova, MO Ustiuzhani, EV Barsov, SA Kust, RA Velichinsk, EI Kovalenko
    Biomedicines, 2021-06-09;9(6):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  12. IL-18 Responsiveness Defines Limitations in Immune Help for Specialized FcR&gamma- NK Cells
    Authors: RR Anderko, CR Rinaldo, RB Mailliard
    J Immunol, 2020-11-13;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  13. Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma
    Authors: HC Tseng, W Xiong, S Badeti, Y Yang, M Ma, T Liu, CA Ramos, G Dotti, L Fritzky, JG Jiang, Q Yi, J Guarrera, WX Zong, C Liu, D Liu
    Nat Commun, 2020-09-23;11(1):4810.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: Flow Cytometry, IHC
  14. CD56dim CD57- NKG2C+ NK cells retaining proliferative potential are possible precursors of CD57+ NKG2C+ memory-like NK cells
    Authors: PA Kobyzeva, MA Streltsova, SA Erokhina, LM Kanevskiy, WG Telford, AM Sapozhniko, EI Kovalenko
    J. Leukoc. Biol., 2020-09-15;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  15. Genetic and Molecular Basis of Heterogeneous NK Cell Responses against Acute Leukemia
    Authors: DR Makanga, F Da Rin de, G David, C Willem, L Dubreuil, N Legrand, T Guillaume, P Peterlin, A Lebourgeoi, MC Béné, A Garnier, P Chevallier, K Gendzekhad, A Cesbron, K Gagne, B Clemenceau, C Retière
    Cancers (Basel), 2020-07-16;12(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  16. Ebola virus glycoprotein stimulates IL-18 dependent natural killer cell responses
    Authors: HR Wagstaffe, EA Clutterbuc, V Bockstal, JN Stoop, K Luhn, MJ Douoguih, G Shukarev, MD Snape, AJ Pollard, EM Riley, M Goodier
    J. Clin. Invest., 2020-07-01;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  17. Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In�Vivo Persistence and Enhances Anti-tumor Activity
    Authors: H Zhu, RH Blum, D Bernareggi, EH Ask, Z Wu, HJ Hoel, Z Meng, C Wu, KL Guan, KJ Malmberg, DS Kaufman
    Cell Stem Cell, 2020-06-11;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  18. Responsiveness to Influenza Vaccination Correlates with NKG2C-Expression on NK Cells
    Authors: P Riese, S Trittel, RD Pathirana, F Klawonn, RJ Cox, CA Guzmán
    Vaccines (Basel), 2020-06-05;8(2):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  19. Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in Crohn Disease Patients.
    Authors: Samarani S, Sagala P, Jantchou P, Grimard G, Faure C, Deslandres C, Amre D, Ahmad A
    Mediators Inflamm, 2020-02-19;2020(0):6401969.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  20. Membrane bound IL-21 based NK cell feeder cells drive robust expansion and metabolic activation of NK cells
    Authors: EO Ojo, AA Sharma, R Liu, S Moreton, MA Checkley-L, K Gupta, G Lee, DA Lee, F Otegbeye, RP Sekaly, M de Lima, DN Wald
    Sci Rep, 2019-10-17;9(1):14916.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Cryopreserved Human Natural Killer Cells Exhibit Potent Antitumor Efficacy against Orthotopic Pancreatic Cancer through Efficient Tumor-Homing and Cytolytic Ability (Running Title: Cryopreserved NK Cells Exhibit Antitumor Effect)
    Authors: E Oh, B Min, Y Li, C Lian, J Hong, GM Park, B Yang, SY Cho, YK Hwang, CO Yun
    Cancers (Basel), 2019-07-09;11(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  22. Between Innate and Adaptive Immune Responses: NKG2A, NKG2C, and CD8? T Cell Recognition of HLA-E Restricted Self-Peptides Acquired in the Absence of HLA-Ia
    Authors: WC Pump, T Kraemer, T Huyton, GT Hò, R Blasczyk, C Bade-Doedi
    Int J Mol Sci, 2019-03-22;20(6):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  23. Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses
    Authors: ECY Wang, M Pjechova, K Nightingal, VM Vlahava, M Patel, E Ruckova, SK Forbes, L Nobre, R Antrobus, D Roberts, CA Fielding, S Seirafian, J Davies, I Murrell, B Lau, GS Wilkie, NM Suárez, RJ Stanton, B Vojtesek, A Davison, PJ Lehner, MP Weekes, GWG Wilkinson, P Tomasec
    Proc. Natl. Acad. Sci. U.S.A., 2018-04-24;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  24. Endometrial natural killer (NK) cells reveal a tissue-specific receptor repertoire
    Authors: D Feyaerts, T Kuret, B van Cranen, S van der Ze, OWH van der He, A van der Me, I Joosten, RG van der Mo
    Hum. Reprod., 2018-03-01;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  25. Complete Remission with Reduction of High-risk Clones following Haploidentical NK Cell Therapy against MDS and AML
    Authors: AT Björklund, M Carlsten, E Sohlberg, LL Liu, T Clancy, M Karimi, S Cooley, JS Miller, M Klimkowska, M Schaffer, E Watz, KI Wikstrom, P Blomberg, BE Wahlin, M Palma, L Hansson, P Ljungman, E Hellström-, HG Ljunggren, KJ Malmberg
    Clin. Cancer Res., 2018-02-14;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  26. The Clinical Features of Patients with Chronic Hepatitis C Virus Infections Are Associated with Killer Cell Immunoglobulin-Like Receptor Genes and Their Expression on the Surface of Natural Killer Cells
    Authors: A Podhorzer, M Dirchwolf, A Machicote, S Belen, S Montal, S Paz, H Fainboim, LG Podestá, L Fainboim
    Front Immunol, 2018-01-05;8(0):1912.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  27. Elevated Neopterin Levels Predict Early Death in Older Hip-fracture Patients
    Authors: M Larsen, C Bayard, H Lepetitcor, J Cohen-Bitt, V Appay, J Boddaert, D Sauce
    EBioMedicine, 2017-11-06;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  28. Antibody-Dependent NK Cell Activation Differentially Targets EBV-Infected Cells in Lytic Cycle and Bystander B Lymphocytes Bound to Viral Antigen-Containing Particles
    Authors: M López-Mont, E Alari-Pahi, J Sintes, JE Martínez-R, A Muntasell, M López-Bote
    J. Immunol., 2017-06-19;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  29. Enhancement of cytokine-driven NK cell IFN-? production after vaccination of HCMV infected Africans
    Authors: A Darboe, E Danso, E Clarke, A Umesi, E Touray, R Wegmuller, SE Moore, EM Riley, MR Goodier
    Eur. J. Immunol., 2017-04-24;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  30. Changes in peripheral immune cell numbers and functions in octogenarian walkers - an acute exercise study
    Authors: KS van der Ge, Q Wang, TM Eijsvogels, HJ Koenen, I Joosten, E Brouwer, MT Hopman, JF Jacobs, AM Boots
    Immun Ageing, 2017-02-22;14(0):5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  31. CD2-CD58 interactions are pivotal for the activation and function of adaptive natural killer cells in human cytomegalovirus infection
    Eur J Immunol, 2016-08-29;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  32. Influenza Vaccination Generates Cytokine-Induced Memory-like NK Cells: Impact of Human Cytomegalovirus Infection
    Authors: Martin R Goodier
    J Immunol, 2016-05-27;197(1):313-25.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  33. New insights on the natural killer cell repertoire from a thorough analysis of cord blood cells
    Authors: P Rettman, C Willem, G David, R Riou, N Legrand, J Esbelin, A Cesbron, D Senitzer, K Gagne, C Retière
    J Leukoc Biol, 2016-04-11;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  34. Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts.
    Authors: Picardi A, Mengarelli A, Marino M, Gallo E, Benevolo M, Pescarmona E, Cocco R, Fraioli R, Tremante E, Petti M, De Fabritiis P, Giacomini P
    J Exp Clin Cancer Res, 2015-09-11;34(0):98.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  35. Natural Killer p46 Controls Hepatitis B Virus Replication and Modulates Liver Inflammation.
    Authors: Li W, Jiang Y, Wang X, Jin J, Qi Y, Chi X, Zhang H, Feng X, Niu J
    PLoS ONE, 2015-08-20;10(8):e0135874.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  36. The Human NK Cell Response to Yellow Fever Virus 17D Is Primarily Governed by NK Cell Differentiation Independently of NK Cell Education.
    Authors: Marquardt N, Ivarsson M, Blom K, Gonzalez V, Braun M, Falconer K, Gustafsson R, Fogdell-Hahn A, Sandberg J, Michaelsson J
    J Immunol, 2015-08-17;195(7):3262-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  37. NK Cell and Ig Interplay in Defense against Herpes Simplex Virus Type 1: Epistatic Interaction of CD16A and IgG1 Allotypes of Variable Affinities Modulates Antibody-Dependent Cellular Cytotoxicity and Susceptibility to Clinical Reactivation.
    Authors: Moraru M, Black L, Muntasell A, Portero F, Lopez-Botet M, Reyburn H, Pandey J, Vilches C
    J Immunol, 2015-07-15;195(4):1676-84.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  38. 2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells.
    Authors: Dunphy S, Guinan K, Chorcora C, Jayaraman J, Traherne J, Trowsdale J, Pende D, Middleton D, Gardiner C
    Genes Immun, 2015-05-07;16(5):301-10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  39. Impaired NK Cell Responses to Pertussis and H1N1 Influenza Vaccine Antigens in Human Cytomegalovirus-Infected Individuals.
    Authors: Nielsen C, White M, Bottomley C, Lusa C, Rodriguez-Galan A, Turner S, Goodier M, Riley E
    J Immunol, 2015-04-08;194(10):4657-67.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  40. Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human T-cell subset.
    Authors: van Meijgaarden K, Haks M, Caccamo N, Dieli F, Ottenhoff T, Joosten S
    PLoS Pathog, 2015-03-24;11(3):e1004671.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  41. Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells.
    Authors: Marquardt N, Beziat V, Nystrom S, Hengst J, Ivarsson M, Kekalainen E, Johansson H, Mjosberg J, Westgren M, Lankisch T, Wedemeyer H, Ellis E, Ljunggren H, Michaelsson J, Bjorkstrom N
    J Immunol, 2015-02-11;194(6):2467-71.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  42. Elevated plasma soluble CD14 and skewed CD16+ monocyte distribution persist despite normalisation of soluble CD163 and CXCL10 by effective HIV therapy: a changing paradigm for routine HIV laboratory monitoring?
    Authors: Castley, Alison, Berry, Cassandr, French, Martyn, Fernandez, Sonia, Krueger, Romano, Nolan, David
    PLoS ONE, 2014-12-29;9(12):e115226.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  43. Dopamine inhibits the effector functions of activated NK cells via the upregulation of the D5 receptor.
    Authors: Mikulak J, Bozzo L, Roberto A, Pontarini E, Tentorio P, Hudspeth K, Lugli E, Mavilio D
    J Immunol, 2014-08-15;193(6):2792-800.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  44. Extracellular HCV-core protein induces an immature regulatory phenotype in NK cells: implications for outcome of acute infection.
    Authors: Golden-Mason L, Hahn Y, Strong M, Cheng L, Rosen H
    PLoS ONE, 2014-07-30;9(7):e103219.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  45. Tracking in vivo dynamics of NK cells transferred in patients undergoing stem cell transplantation.
    Authors: Killig M, Friedrichs B, Meisig J, Gentilini C, Bluthgen N, Loddenkemper C, Labopin M, Basara N, Pfrepper C, Niederwieser D, Uharek L, Romagnani C
    Eur J Immunol, 2014-06-30;44(9):2822-34.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  46. Long-term effect on natural killer cells by interferon-alpha therapy on the outcomes of HCV infection.
    Authors: Hu X, Jiang Y, Li X, Gao Y, Guo X, Chi X, Yan H, Feng J, Zhong J, Sun B, Shao X, Xiao W, Pan Y, Niu J
    J Interferon Cytokine Res, 2013-12-24;34(5):366-75.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  47. Expansion of CMV-mediated NKG2C+ NK cells associates with the development of specific de novo malignancies in liver-transplanted patients.
    Authors: Achour, Abla, Baychelier, Florence, Besson, Caroline, Arnoux, Armelle, Marty, Michel, Hannoun, Laurent, Samuel, Didier, Debre, Patrice, Vieillard, Vincent
    J Immunol, 2013-12-04;192(1):503-11.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  48. Human cytomegalovirus infection elicits new decidual natural killer cell effector functions.
    Authors: Siewiera J, El Costa H, Tabiasco J, Berrebi A, Cartron G, Le Bouteiller P, Jabrane-Ferrat N
    PLoS Pathog, 2013-04-04;9(4):e1003257.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  49. Modulation of the natural killer cell KIR repertoire by cytomegalovirus infection.
    Authors: Charoudeh H, Terszowski G, Czaja K, Gonzalez A, Schmitter K, Stern M
    Eur J Immunol, 2012-12-12;43(2):480-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  50. Natural killer cells are characterized by the concomitantly increased interferon-gamma and cytotoxicity in acute resolved hepatitis B patients.
    Authors: Zhao J, Li Y, Jin L, Zhang S, Fan R, Sun Y, Zhou C, Shang Q, Li W, Zhang Z, Wang F
    PLoS ONE, 2012-11-01;7(11):e49135.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  51. Human Cytomegalovirus (CMV)-Induced Memory-like NKG2C+ NK Cells Are Transplantable and Expand In Vivo in Response to Recipient CMV Antigen.
    Authors: Foley, Bree, Cooley, Sarah, Verneris, Michael, Curtsinger, Julie, Luo, Xianghua, Waller, Edmund K, Anasetti, Claudio, Weisdorf, Daniel, Miller, Jeffrey
    J Immunol, 2012-10-17;189(10):5082-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  52. CMV drives clonal expansion of NKG2C+ NK cells expressing self-specific KIRs in chronic hepatitis patients.
    Authors: Beziat V, Dalgard O, Asselah T, Halfon P, Bedossa P, Boudifa A, Hervier B, Theodorou I, Martinot M, Debre P, Bjorkstrom NK, Malmberg KJ, Marcellin P, Vieillard V
    Eur. J. Immunol., 2011-12-16;42(2):447-57.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  53. Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus.
    Authors: Bjorkstrom NK, Lindgren T, Stoltz M, Fauriat C, Braun M, Evander M, Michaelsson J, Malmberg KJ, Klingstrom J, Ahlm C, Ljunggren HG
    J. Exp. Med., 2010-12-20;208(1):13-21.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  54. Analysis of CD16+CD56dim NK cells from CLL patients: evidence supporting a therapeutic strategy with optimized anti-CD20 monoclonal antibodies.
    Authors: Le Garff-Tavernier M, Decocq J, de Romeuf C, Parizot C, Dutertre CA, Chapiro E, Davi F, Debre P, Prost JF, Teillaud JL, Merle-Beral H, Vieillard V
    Leukemia, 2010-10-26;25(1):101-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  55. NKG2A inhibits NKG2C effector functions of gammadelta T cells: implications in health and disease.
    Authors: Angelini DF, Zambello R, Galandrini R, Diamantini A, Placido R, Micucci F, Poccia F, Semenzato G, Borsellino G, Santoni A, Battistini L
    J. Leukoc. Biol., 2010-10-15;89(1):75-84.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  56. NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs.
    Authors: Beziat V, Descours B, Parizot C, Debre P, Vieillard V
    PLoS ONE, 2010-08-06;5(8):e11966.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  57. High log-scale expansion of functional human natural killer cells from umbilical cord blood CD34-positive cells for adoptive cancer immunotherapy.
    Authors: Spanholtz J, Tordoir M, Eissens D, Preijers F, van der Meer A, Joosten I, Schaap N, de Witte TM, Dolstra H
    PLoS ONE, 2010-02-15;5(2):e9221.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  58. Shaping of iNKT cell repertoire after unrelated cord blood transplantation.
    Authors: Beziat V, Nguyen S, Exley M, Achour A, Simon T, Chevallier P, Sirvent A, Vigouroux S, Debre P, Rio B, Vieillard V, Lubrano-Berthelier C, Alatrakchi N
    Clin. Immunol., 2010-02-13;135(3):364-73.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  59. The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia.
    Authors: Brunetta E, Fogli M, Varchetta S, Bozzo L, Hudspeth KL, Marcenaro E, Moretta A, Mavilio D
    Blood, 2009-08-26;114(18):3822-30.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  60. An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation.
    Authors: Dulphy N, Haas P, Busson M, Belhadj S, Peffault de Latour R, Robin M, Carmagnat M, Loiseau P, Tamouza R, Scieux C, Rabian C, Di Santo JP, Charron D, Janin A, Socie G, Toubert A
    J. Immunol., 2008-08-01;181(3):2227-37.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  61. Establishment and characterization of SRIK-NKL: a novel CD8+ natural killer/T cell line derived from a patient with leukemic phase of acute lymphoblastic lymphoma.
    Authors: Srivastava BI, Srivastava MD
    Leuk. Res., 2005-07-01;29(7):771-83.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  62. Pro- and Anti-Inflammatory Cytokines in the Context of NK Cell-Trophoblast Interactions
    Authors: V Mikhailova, P Grebenkina, E Khokhlova, A Davydova, Z Salloum, E Tyshchuk, V Zagainova, K Markova, I Kogan, S Selkov, D Sokolov
    International Journal of Molecular Sciences, 2022-02-21;23(4):.
  63. Functional and Phenotypic Changes of Natural Killer Cells in Whole Blood during Mycobacterium tuberculosis Infection and Disease
    Authors: Mathieu Garand, Martin Goodier, Olumuyiwa Owolabi, Simon Donkor, Beate Kampmann, Jayne S. Sutherland
    Frontiers in Immunology
  64. Tissue Determinants of Human NK Cell Development, Function, and Residence
    Authors: Pranay Dogra, Chiara Rancan, Wenji Ma, Marta Toth, Takashi Senda, Dustin J. Carpenter et al.
    Cell
  65. CD56dimCD57+NKG2C+ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT
    Authors: Frank Cichocki, Sarah Cooley, Zachary Davis, Todd E. DeFor, Heinrich Schlums, Bin Zhang et al.
    Leukemia
  66. Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting Fc epsilon RI gamma expression
    Authors: Avishai Shemesh, Yapeng Su, Daniel R. Calabrese, Daniel Chen, Janice Arakawa-Hoyt, Kole T. Roybal et al.
    Journal of Experimental Medicine
  67. TIGIT blockade enhances functionality of peritoneal NK cells with altered expression of DNAM-1/TIGIT/CD96 checkpoint molecules in ovarian cancer
    Authors: Ralph Ja Maas, Janneke S Hoogstad-van Evert, Jolien Mr Van der Meer, Vera Mekers, Somayeh Rezaeifard, Alan J Korman et al.
    OncoImmunology
  68. RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses
    Authors: Todd Bradley, Dimitra Peppa, Isabela Pedroza-Pacheco, Dapeng Li, Derek W. Cain, Ricardo Henao et al.
    Cell

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Human NKG2C/CD159c PE‑conjugated Antibody
By Lu Bai on 07/26/2022
Application: Flow Sample Tested: Peripheral blood mononuclear cells (PBMCs) Species: Human

Human NKG2C/CD159c PE-conjugated Antibody
By Stephane Hua on 07/05/2018
Application: Flow Sample Tested: Natural killer cells Species: Human