Human NKG2C/CD159c PE-conjugated Antibody

(34 citations)   
  • Species Reactivity
    Human
  • Specificity
    Detects human NKG2C/CD159c heterodimer with CD94 in flow cytometry. It does not cross-react with the human NKG2A/CD94 heterodimer or with the human CD94 homodimer.
  • Source
    Monoclonal Mouse IgG1 Clone # 134591
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    BaF3 mouse pro-B cell line transfected with human NKG2C/CD159c and CD94
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
    Phycoerythrin
Applications
  •  
    Recommended
    Concentration
    Sample
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of NKG2C/CD159c in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human NCAM‑1/CD56 APC‑conjugated Monoclonal Antibody (Catalog # FAB2408A) and either (A) Mouse Anti-Human NKG2C/CD159c PE‑conjugated Monoclonal Antibody (Catalog # FAB138P) or (B) Mouse IgG1 Phycoerythrin Isotype Control (Catalog # IC002P). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: NKG2C/CD159c
NKG2C, also known as hemoglobin scavenger receptor, is a type II transmembrane protein expressed exclusively in monocytes and macrophages. It is a scavenger receptor cysteine-rich superfamily (SRCR-SF) protein that contains nine SRCR motifs in its extracellular region.
  • Long Name:
    Natural Killer G2C
  • Entrez Gene IDs:
    3822 (Human); 16642 (Mouse)
  • Alternate Names:
    CD159 antigen-like family member C; CD159c antigen; CD159c; killer cell lectin-like receptor subfamily C, member 2; KLRC2; MGC138244; NK cell receptor C; NKG2-C type II integral membrane protein; NKG2C; NKG2-C; NKG2CNKG2-C-activating NK receptor
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

34 Citations: Showing 1 - 10
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Species
Applications
Sample Type
  1. Antibody-Dependent NK Cell Activation Differentially Targets EBV-Infected Cells in Lytic Cycle and Bystander B Lymphocytes Bound to Viral Antigen-Containing Particles
    Authors: M López-Mont, E Alari-Pahi, J Sintes, JE Martínez-R, A Muntasell, M López-Bote
    J. Immunol., 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  2. Enhancement of cytokine-driven NK cell IFN-? production after vaccination of HCMV infected Africans
    Authors: A Darboe, E Danso, E Clarke, A Umesi, E Touray, R Wegmuller, SE Moore, EM Riley, MR Goodier
    Eur. J. Immunol., 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  3. Changes in peripheral immune cell numbers and functions in octogenarian walkers - an acute exercise study
    Authors: KS van der Ge, Q Wang, TM Eijsvogels, HJ Koenen, I Joosten, E Brouwer, MT Hopman, JF Jacobs, AM Boots
    Immun Ageing, 2017;14(0):5.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow Ctyometry
  4. Influenza Vaccination Generates Cytokine-Induced Memory-like NK Cells: Impact of Human Cytomegalovirus Infection
    Authors: Martin R Goodier
    J Immunol, 2016;197(1):313-25.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  5. CD2-CD58 interactions are pivotal for the activation and function of adaptive natural killer cells in human cytomegalovirus infection
    Eur J Immunol, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  6. New insights on the natural killer cell repertoire from a thorough analysis of cord blood cells
    Authors: P Rettman, C Willem, G David, R Riou, N Legrand, J Esbelin, A Cesbron, D Senitzer, K Gagne, C Retière
    J Leukoc Biol, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  7. Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells.
    Authors: Marquardt N, Beziat V, Nystrom S, Hengst J, Ivarsson M, Kekalainen E, Johansson H, Mjosberg J, Westgren M, Lankisch T, Wedemeyer H, Ellis E, Ljunggren H, Michaelsson J, Bjorkstrom N
    J Immunol, 2015;194(6):2467-71.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  8. Impaired NK Cell Responses to Pertussis and H1N1 Influenza Vaccine Antigens in Human Cytomegalovirus-Infected Individuals.
    Authors: Nielsen C, White M, Bottomley C, Lusa C, Rodriguez-Galan A, Turner S, Goodier M, Riley E
    J Immunol, 2015;194(10):4657-67.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  9. 2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells.
    Authors: Dunphy S, Guinan K, Chorcora C, Jayaraman J, Traherne J, Trowsdale J, Pende D, Middleton D, Gardiner C
    Genes Immun, 2015;16(5):301-10.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  10. The Human NK Cell Response to Yellow Fever Virus 17D Is Primarily Governed by NK Cell Differentiation Independently of NK Cell Education.
    Authors: Marquardt N, Ivarsson M, Blom K, Gonzalez V, Braun M, Falconer K, Gustafsson R, Fogdell-Hahn A, Sandberg J, Michaelsson J
    J Immunol, 2015;195(7):3262-72.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  11. Natural Killer p46 Controls Hepatitis B Virus Replication and Modulates Liver Inflammation.
    Authors: Li W, Jiang Y, Wang X, Jin J, Qi Y, Chi X, Zhang H, Feng X, Niu J
    PLoS ONE, 2015;10(8):e0135874.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  12. Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts.
    Authors: Picardi A, Mengarelli A, Marino M, Gallo E, Benevolo M, Pescarmona E, Cocco R, Fraioli R, Tremante E, Petti M, De Fabritiis P, Giacomini P
    J Exp Clin Cancer Res, 2015;34(0):98.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  13. Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human T-cell subset.
    Authors: van Meijgaarden K, Haks M, Caccamo N, Dieli F, Ottenhoff T, Joosten S
    PLoS Pathog, 2015;11(3):e1004671.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  14. NK Cell and Ig Interplay in Defense against Herpes Simplex Virus Type 1: Epistatic Interaction of CD16A and IgG1 Allotypes of Variable Affinities Modulates Antibody-Dependent Cellular Cytotoxicity and Susceptibility to Clinical Reactivation.
    Authors: Moraru M, Black L, Muntasell A, Portero F, Lopez-Botet M, Reyburn H, Pandey J, Vilches C
    J Immunol, 2015;195(4):1676-84.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  15. Tracking in vivo dynamics of NK cells transferred in patients undergoing stem cell transplantation.
    Authors: Killig M, Friedrichs B, Meisig J, Gentilini C, Bluthgen N, Loddenkemper C, Labopin M, Basara N, Pfrepper C, Niederwieser D, Uharek L, Romagnani C
    Eur J Immunol, 2014;44(9):2822-34.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  16. Expansion of CMV-mediated NKG2C+ NK cells associates with the development of specific de novo malignancies in liver-transplanted patients.
    Authors: Achour, Abla, Baychelier, Florence, Besson, Caroline, Arnoux, Armelle, Marty, Michel, Hannoun, Laurent, Samuel, Didier, Debre, Patrice, Vieillard, Vincent
    J Immunol, 2014;192(1):503-11.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  17. Long-term effect on natural killer cells by interferon-alpha therapy on the outcomes of HCV infection.
    Authors: Hu X, Jiang Y, Li X, Gao Y, Guo X, Chi X, Yan H, Feng J, Zhong J, Sun B, Shao X, Xiao W, Pan Y, Niu J
    J Interferon Cytokine Res, 2014;34(5):366-75.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  18. Extracellular HCV-core protein induces an immature regulatory phenotype in NK cells: implications for outcome of acute infection.
    Authors: Golden-Mason L, Hahn Y, Strong M, Cheng L, Rosen H
    PLoS ONE, 2014;9(7):e103219.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  19. Dopamine inhibits the effector functions of activated NK cells via the upregulation of the D5 receptor.
    Authors: Mikulak J, Bozzo L, Roberto A, Pontarini E, Tentorio P, Hudspeth K, Lugli E, Mavilio D
    J Immunol, 2014;193(6):2792-800.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  20. Elevated plasma soluble CD14 and skewed CD16+ monocyte distribution persist despite normalisation of soluble CD163 and CXCL10 by effective HIV therapy: a changing paradigm for routine HIV laboratory monitoring?
    Authors: Castley, Alison, Berry, Cassandr, French, Martyn, Fernandez, Sonia, Krueger, Romano, Nolan, David
    PLoS ONE, 2014;9(12):e115226.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  21. Modulation of the natural killer cell KIR repertoire by cytomegalovirus infection.
    Authors: Charoudeh H, Terszowski G, Czaja K, Gonzalez A, Schmitter K, Stern M
    Eur J Immunol, 2013;43(2):480-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  22. Human cytomegalovirus infection elicits new decidual natural killer cell effector functions.
    Authors: Siewiera J, El Costa H, Tabiasco J, Berrebi A, Cartron G, Le Bouteiller P, Jabrane-Ferrat N
    PLoS Pathog, 2013;9(4):e1003257.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  23. CMV drives clonal expansion of NKG2C+ NK cells expressing self-specific KIRs in chronic hepatitis patients.
    Authors: Beziat V, Dalgard O, Asselah T, Halfon P, Bedossa P, Boudifa A, Hervier B, Theodorou I, Martinot M, Debre P, Bjorkstrom NK, Malmberg KJ, Marcellin P, Vieillard V
    Eur. J. Immunol., 2012;42(2):447-57.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  24. Natural killer cells are characterized by the concomitantly increased interferon-gamma and cytotoxicity in acute resolved hepatitis B patients.
    Authors: Zhao J, Li Y, Jin L, Zhang S, Fan R, Sun Y, Zhou C, Shang Q, Li W, Zhang Z, Wang F
    PLoS ONE, 2012;7(11):e49135.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  25. Human Cytomegalovirus (CMV)-Induced Memory-like NKG2C+ NK Cells Are Transplantable and Expand In Vivo in Response to Recipient CMV Antigen.
    Authors: Foley, Bree, Cooley, Sarah, Verneris, Michael, Curtsinger, Julie, Luo, Xianghua, Waller, Edmund K, Anasetti, Claudio, Weisdorf, Daniel, Miller, Jeffrey
    J Immunol, 2012;189(10):5082-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  26. Analysis of CD16+CD56dim NK cells from CLL patients: evidence supporting a therapeutic strategy with optimized anti-CD20 monoclonal antibodies.
    Authors: Le Garff-Tavernier M, Decocq J, de Romeuf C, Parizot C, Dutertre CA, Chapiro E, Davi F, Debre P, Prost JF, Teillaud JL, Merle-Beral H, Vieillard V
    Leukemia, 2011;25(1):101-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  27. NKG2A inhibits NKG2C effector functions of gammadelta T cells: implications in health and disease.
    Authors: Angelini DF, Zambello R, Galandrini R, Diamantini A, Placido R, Micucci F, Poccia F, Semenzato G, Borsellino G, Santoni A, Battistini L
    J. Leukoc. Biol., 2011;89(1):75-84.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  28. Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus.
    Authors: Bjorkstrom NK, Lindgren T, Stoltz M, Fauriat C, Braun M, Evander M, Michaelsson J, Malmberg KJ, Klingstrom J, Ahlm C, Ljunggren HG
    J. Exp. Med., 2011;208(1):13-21.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  29. Shaping of iNKT cell repertoire after unrelated cord blood transplantation.
    Authors: Beziat V, Nguyen S, Exley M, Achour A, Simon T, Chevallier P, Sirvent A, Vigouroux S, Debre P, Rio B, Vieillard V, Lubrano-Berthelier C, Alatrakchi N
    Clin. Immunol., 2010;135(3):364-73.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  30. NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs.
    Authors: Beziat V, Descours B, Parizot C, Debre P, Vieillard V
    PLoS ONE, 2010;5(8):e11966.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  31. High log-scale expansion of functional human natural killer cells from umbilical cord blood CD34-positive cells for adoptive cancer immunotherapy.
    Authors: Spanholtz J, Tordoir M, Eissens D, Preijers F, van der Meer A, Joosten I, Schaap N, de Witte TM, Dolstra H
    PLoS ONE, 2010;5(2):e9221.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  32. The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia.
    Authors: Brunetta E, Fogli M, Varchetta S, Bozzo L, Hudspeth KL, Marcenaro E, Moretta A, Mavilio D
    Blood, 2009;114(18):3822-30.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  33. An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation.
    Authors: Dulphy N, Haas P, Busson M, Belhadj S, Peffault de Latour R, Robin M, Carmagnat M, Loiseau P, Tamouza R, Scieux C, Rabian C, Di Santo JP, Charron D, Janin A, Socie G, Toubert A
    J. Immunol., 2008;181(3):2227-37.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  34. Establishment and characterization of SRIK-NKL: a novel CD8+ natural killer/T cell line derived from a patient with leukemic phase of acute lymphoblastic lymphoma.
    Authors: Srivastava BI, Srivastava MD
    Leuk. Res., 2005;29(7):771-83.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
Expand to show all 34 Citations
Isotype Controls
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Mouse IgG1 PE-conjugated Antibody

Ctrl IC002P 38  
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Flow Cytometry Staining Buffer (1X)

Flow FC001 6
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Flow Cytometry Mouse Lyse Buffer (10X)

Flow FC003 4
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Flow Cytometry Human Lyse Buffer (10X)

Flow FC002 1
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