Human OX40/TNFRSF4 (NP_003318) VersaClone cDNA

Name: Human OX40/TNFRSF4 (NP_003318) VersaClone cDNA
Brand: R&D Systems
SKU: RDC0360
Price: 270 USD
Availability: InStock

R&D Systems | Catalog # RDC0360

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Background
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Research Areas

Key Product Details

Species

Human

Accession Number

NP_003318

Background: OX40

OX40 (CD134; TNFRSF4) is a T cell costimulatory molecule of the TNF receptor superfamily that coordinates with other costimulators (CD28, CD40, CD30, CD27 and 4-1BB) to manage the activation of the immune response. OX40 is upregulated on antigen activated CD4+ and CD8+ T cells with costimulation by CD40-CD40 Ligand and CD28-B7. OX40 interactions with OX40 Ligand on antigen presenting cells enhances T cell survival, proliferation, and cytokine production. It also inhibits the conversion of effector T cells into regulatory T cells (Tregs) and can promote the maintenance of and recall response in memory T cells. OX40 is constitutively expressed on Tregs where it promotes Treg proliferation and immunosuppressive activity. OX40-OX40 Ligand signaling is involved in allergic airway inflammation, graft-versus-host disease, and autoimmune disease.