Does this Biosimilar antibody have the same sequence as the therapeutic antibody?

Name: Human PDGF R alpha (Research Grade Olaratumab Biosimilar) Antibody
Brand: R&D Systems
SKU: MAB10352-SP

The Biosimilar antibody has the same variable region and constant region sequence as the therapeutic antibody.

Human PDGF R alpha (Research Grade Olaratumab Biosimilar) Antibody

MAB10352 Datasheet / COA / SDS

Recombinant Monoclonal Antibody For Research Use Only

Catalog #	Availability	Size / Price	Qty
MAB10352-100
MAB10352-SP

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Detection of PDGF R alpha in U-118-MG human glioblastoma cell line by Flow Cytometry.

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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human PDGF R alpha (Research Grade Olaratumab Biosimilar) Antibody Summary

Species Reactivity

Human

Specificity

Detects Human PDGF R alpha in direct ELISAs.This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Olaratumab. This product is for research use only.

Source

Recombinant Monoclonal Human IgG₁ Clone # Hu136

Purification

Protein A or G purified from cell culture supernatant

Immunogen

Human PDGF R alpha

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

Endotoxin Level

<0.10 EU per 1 μg of the antibody by the LAL method.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Flow Cytometry

0.25 µg/10⁶ cells

See below

CyTOF-ready

Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Flow Cytometry

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Detection of PDGF R alpha in U-118-MG human glioblastoma cell line by Flow Cytometry. U-118-MG human glioblastoma cell line was stained with Human Anti-Human PDGF R alpha (Research Grade Olaratumab Biosimilar) Monoclonal Antibody (Catalog # MAB10352, filled histogram) or irrelevant antibody (open histogram) followed by APC-conjugated Anti-Human IgG Secondary Antibody (Catalog # F0135). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Reconstitution Buffer Available

Reconstitution Buffer 1 (PBS)

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: PDGF R alpha

Olaratumab is a biosimilar directed against human PDGF R alpha.

Long Name

Platelet-derived Growth Factor Receptor alpha

Entrez Gene IDs

5156 (Human); 18595 (Mouse)

Alternate Names

alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen; CD140a; EC 2.7.10; EC 2.7.10.1; MGC74795; PDGF R alpha; PDGFR alpha; PDGFR2; PDGFRA; PDGFRA/BCR fusion; PDGF-R-alpha; platelet-derived growth factor receptor, alpha polypeptide; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alphafusion protein; RHEPDGFRA

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

FAQs

Does this Biosimilar antibody have the same sequence as the therapeutic antibody?
- The Biosimilar antibody has the same variable region and constant region sequence as the therapeutic antibody.

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