Human Perilipin-3 Alexa Fluor® 700-conjugated Antibody

Catalog #: FAB7664N Datasheet / COA / SDS

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FAB7664N-100UG

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Human Perilipin-3 Alexa Fluor® 700-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Perilipin‑3 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) Perilipin-2 or rhPerilipin-5 is observed.

Source

Monoclonal Mouse IgG2b Clone # 779119

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human Perilipinâ€‘3
Met1-Lys434
Accession # O60664

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 700 (Excitation= 675-700 nm, Emission= 723 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Perilipin-3

M6PRBP1 (mannose 6-phosphate receptor binding protein), gene name PLIN3 (Perilipin-3), also called TIP47 (tail interacting protein of 47 kDa) or PP17 (placental protein 17), is a 47 kDa intracellular transport protein that belongs to the PAT (Perilipin/Adipophilin/TIP47) family of molecules. The 434 amino acid (aa) human Perilipin‑3, which shares approximately 75% aa sequence identity with mouse and rat Perilipin-3, contains a four-helix bundle thought to interact with membranes, and may be phosphorylated and acetylated. A 251 aa form (isoform A) has an alternate start site at aa 184 of the 434 aa form (isoform B). Perilipin-3 is normally found predominantly in the cytoplasm. It is required for uptake of mannose-6 phosphate receptors into endosomes. In the presence of excess lipids, such as in macrophage-derived foam cells, Perilipin-3 may transfer free fatty acids to lipid droplets, promoting their growth.

Entrez Gene IDs

10226 (Human); 66905 (Mouse); 316130 (Rat)

Alternate Names

Cargo selection protein TIP47; M6PRBP1; M6PRBP1MGC2012; Mannose-6-phosphate receptor-binding protein 1; perilipin 3,47 kDa MPR-binding protein; Perilipin3; Perilipin-3; Placental protein 17,47 kDa mannose 6-phosphate receptor-binding protein; PLIN3; PP17; PP17MGC11117; tail-interacting protein, 47 kD; TIP47; TIP47mannose-6-phosphate receptor binding protein 1