Human Phospho-RelA/NFkB p65 (S536) Alexa Fluor® 350-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: RelA/NFkB p65

RelA belongs to a family of transcription factors (NF kappa B (nuclear factor kappa from B cells) complex) that play a fundamental role in inflammatory and immune responses. The NF kappa B complex is composed of a heterodimer of a Rel family member (RelA, c-Rel, RelB) and either NF kappa B1 or NF kappa B2 subunits. RelA and NF kappa B1 are the most common heterodimeric pair. The NF kappa B complex is sequestered in the cytoplasm by inhibitory I kappa B proteins. Upon cellular activation, the ubiquitin-proteosome pathway degrades the I kappa B proteins allowing the NF kappa B complex to translocate to the nucleus and activate gene transcription.

Product Datasheets

Related Research Areas

• Apoptosis Transcription Factors and Regulators
• Chemokine Receptor Intracellular Signaling
• C-type Lectin Receptors
• IL-1 Family
• IL-17 Family
• Immunoglobulin-Like Domain Transcription Factors
• Interferons
• Natural Killer T (NKT) Cells
• NFkB Pathway
• NOD-like Receptors and the Inflammasome
• PDGF Family
• RIG-I-like Receptors
• TNF Superfamily Regulators
• Toll-Like Receptors
• Transcription Factors and Regulators
• Transcription Factors in the Akt Pathway