Human Pro BDNF Alexa Fluor® 700-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: BDNF

BDNF is a member of the NGF family of neurotrophic factors that are required for the differentiation and survival of neuronal subpopulations in the central and peripheral nervous systems. BDNF functions through interactions with the TrkB receptor tyrosine kinase and the low affinity neurotrophin receptor, p75 (NTR). The human BDNF cDNA encodes 247 amino acids (aa). Cleavage of an 18 aa signal sequence produces an approximately 35 kDa Pro-BDNF form. The N-terminal pro region of BDNF is removed by tPA and furin to release biologically active, 14 kDa BDNF. The propeptides of human and mouse BDNF share 93% aa sequence identity.

Product Datasheets

Related Research Areas

• Adult Neurogenesis
• Developmental Factors Implicated in Neurodegeneration
• Diabetes
• Diabetic Peripheral Neuropathy
• Microglia Activation Markers
• Microglia Homeostasis
• Microglia Steady-State Markers
• Neuroinflammatory Factors
• Neurotrophic Factors and Receptors
• Neurotrophin/Trk Family
• Obesity
• VPS10P-domain Family