Human/Rat CaMKK alpha Alexa Fluor® 647-conjugated Antibody

Catalog #: AF4536R Datasheet / COA / SDS

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AF4536R-100UG

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Human/Rat CaMKK alpha Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human, Rat

Specificity

Detects endogenous human and rat CaMKK alpha in Western blots. In Western blots, this antibody does not cross-react with recombinant human CaMKK beta.

Source

Polyclonal Sheep IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human CaMKKÎ±
Met1-Ser132
Accession # Q8N5S9

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: CaMKK alpha

The calcium/calmodulin (CaM) kinase signaling cascade includes the upstream kinases CaM kinase kinase alpha (CaMKK alpha ; also known as CaMKK1) and CaMKK beta (CaMKK2), and their substrates, the output kinases CaMKI and CaMKIV. Largely by activation of the transcription factor CREB, the CaM kinase cascade is implicated in neuronal development and long-term memory formation. In addition, CaMKK alpha is known to modulate skeletal muscle glucose uptake, and is upregulated during retinoic acid-induced neutrophil maturation.

Long Name

Calcium/Calmodulin-dependent Protein Kinase Kinase alpha

Entrez Gene IDs

84254 (Human); 55984 (Mouse); 60341 (Rat)

Alternate Names

calcium/calmodulin-dependent protein kinase kinase 1; calcium/calmodulin-dependent protein kinase kinase 1, alpha; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-kinase IV kinase; CaM-kinase kinase 1; CaM-kinase kinase alpha; CaM-KK 1; CAMKK alpha protein; CaMKK alpha; CaM-KK alpha; CaMKK1; CAMKKACaMKK 1; DKFZp761M0423; EC 2.7.11; EC 2.7.11.17; MGC34095