Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Alexa Fluor 405 (Excitation = 405 nm, Emission = 421 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 883335
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Product Specifications

Immunogen

E. coli-derived recombinant human SAMHD1
His206-Arg339
Accession # Q9Y3Z3

Specificity

Detects human SAMHD1 in ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Human SAMHD1 Alexa Fluor® 405‑conjugated Antibody

Application
Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: SAMHD1

Human SAM (Sterile Alpha Motif) domain and HD (His/Asp motif-containing phosphohydrolase) domain-containing 1 (SAMHD1), also known as DCIP (dendritic cell IFN-g-induced protein) or MOP5 (monocyte protein 5) is a 70-80 kDa, 626 amino acid (aa) nuclear protein that acts as a dGTP-regulated deoxynucleotide triphosphohydrolase. It restricts HIV replication by binding nucleic acids. SAMHD-1 expression is induced by TNF-a in myeloid lineage cells and lung fibroblasts. Human SAMHD1 mutations are linked to Aicardi-Goutieres Syndrome, which is characterized by symptoms mimicking viral infection. Human SAMHD1 isoforms of 602, 591, and 556 aa lack aa 113-136, 502-536, and 285-354, respectively. The 591 and 556 aa forms are catalytically inactive. Within the region used as an immunogen, human SAMHD1 shares 85% aa sequence identity with mouse and rat SAMHD1.

Long Name

SAM Domain and HD Domain 1

Alternate Names

AGS5, CHBL2, DCIP, HDDC1, MOP-5, SBBI88

Entrez Gene IDs

25939 (Human); 56045 (Mouse); 311580 (Rat)

Gene Symbol

SAMHD1

UniProt

Additional SAMHD1 Products

Product Documents for Human SAMHD1 Alexa Fluor® 405‑conjugated Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human SAMHD1 Alexa Fluor® 405‑conjugated Antibody


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

For research use only

Related Research Areas

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