Human SAMHD1 Alexa Fluor® 700-conjugated Antibody

Catalog #: FAB8120N Datasheet / COA / SDS

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FAB8120N-100UG

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Human SAMHD1 Alexa Fluor® 700-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human SAMHD1 in ELISAs.

Source

Monoclonal Mouse IgG2b Clone # 883335

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human SAMHD1
His206-Arg339
Accession # Q9Y3Z3

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 700 (Excitation= 675-700 nm, Emission= 723 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: SAMHD1

Human SAM (Sterile Alpha Motif) domain and HD (His/Asp motif-containing phosphohydrolase) domain-containing 1 (SAMHD1), also known as DCIP (dendritic cell IFN-g-induced protein) or MOP5 (monocyte protein 5) is a 70-80 kDa, 626 amino acid (aa) nuclear protein that acts as a dGTP-regulated deoxynucleotide triphosphohydrolase. It restricts HIV replication by binding nucleic acids. SAMHD-1 expression is induced by TNF-a in myeloid lineage cells and lung fibroblasts. Human SAMHD1 mutations are linked to Aicardi-Goutieres Syndrome, which is characterized by symptoms mimicking viral infection. Human SAMHD1 isoforms of 602, 591, and 556 aa lack aa 113-136, 502-536, and 285-354, respectively. The 591 and 556 aa forms are catalytically inactive. Within the region used as an immunogen, human SAMHD1 shares 85% aa sequence identity with mouse and rat SAMHD1.

Long Name

SAM Domain and HD Domain 1

Entrez Gene IDs

25939 (Human); 56045 (Mouse); 311580 (Rat)

Alternate Names

AGS5; CHBL2; DCIP; DCIPMg11; Dendritic cell-derived IFNG-induced protein; EC 3.1.4.-; HDDC1; Monocyte protein 5; MOP5; MOP-5; MOP-5AGS5; SAM domain and HD domain 1; SAM domain and HD domain-containing protein 1; SAMHD1; SBBI88