Human SNF1LK2 Alexa Fluor™ Plus 405‑conjugated Antibody

R&D Systems | Catalog # AF5737AFP405

R&D Systems
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Immunocytochemistry

Label

Alexa Fluor Plus 405 (Excitation = 404 nm, Emission = 455 nm)

Antibody Source

Polyclonal Goat IgG
View all SNF1LK2/SIK2 Primary Antibodies »

Product Specifications

Specificity

Detects human SNF1LK2 in Western blots.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Human SNF1LK2 Alexa Fluor™ Plus 405‑conjugated Antibody

Application
Recommended Usage

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: SNF1LK2/SIK2

SNF1LK2 (Sucrose non-fermenting 1 like kinase 2) also known as SIK2 (Salt-inducible kinase 2) is a cytoplasmic 125 kDa member of the CAMK Ser/Thr protein kinase family, AMPK subfamily of enzymes. It is expressed in preadipocytes/adipocytes, with levels strongly induced during early differentiation. SNF1LK2 regulates the early phase of insulin signaling by phosphorylating IRS-1 on Ser794. Human SNF1LK2 is 926 amino acids (aa) in length and contains a protein kinase domain (aa 20‑271) with an ATP binding site (Lys49) and a catalytic loop (aa 140‑149), followed by a phosphorylation activation site at Thr175, a UBA (ubiquitin-associated) domain (aa 295‑335) and another PKA-dependent phosphorylation site at Ser587.

Long Name

SNF1-like Kinase 2

Alternate Names

LOH11CR1I, QIK, SIK2

Entrez Gene IDs

23235 (Human); 235344 (Mouse)

Gene Symbol

SIK2

UniProt

Q9H0K1

Additional SNF1LK2/SIK2 Products

Product Documents for Human SNF1LK2 Alexa Fluor™ Plus 405‑conjugated Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human SNF1LK2 Alexa Fluor™ Plus 405‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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Protocols

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FAQs

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