Human TACI/TNFRSF13B PE-conjugated Antibody

Clone 165604 was used by HLDA to establish CD designation
Catalog # Availability Size / Price Qty
FAB1741P
Human TACI/TNFRSF13B PE-conjugated Antibody in Data
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Product Details
Citations (6)
FAQs
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Human TACI/TNFRSF13B PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human TACI/TNFRSF13B in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human BCMA or recombinant mouse TACI is observed.
Source
Monoclonal Mouse IgG1 Clone # 165604
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human TACI/TNFRSF13B
Ser2-Thr166
Accession # O14836
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Examples

Flow Cytometry Detection of TACI/TNFRSF13B antibody in Human Peripheral Blood Lymphocytes antibody by Flow Cytometry. View Larger

Detection of TACI/TNFRSF13B in Human Peripheral Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human TACI/TNFRSF13B PE-conjugated Monoclonal Antibody (Catalog # FAB1741P) and Mouse Anti-Human CD19 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB4867F). Quadrant markers were set based on control antibody staining (Catalog # IC002P). View our protocol for Staining Membrane-associated Proteins.

Flow Cytometry Detection of TACI/TNFRSF13B antibody in Raji Human Cell Line antibody by Flow Cytometry. View Larger

Detection of TACI/TNFRSF13B in Raji Human Cell Line by Flow Cytometry. Raji human Burkitt's lymphoma cell line was stained with Mouse Anti-Human TACI/TNFRSF13B PE-conjugated Monoclonal Antibody (Catalog # FAB1741P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: TACI/TNFRSF13B

TACI (Transmembrane Activator and CAML-Interactor) is a 30-32 kDa member of the TNF receptor superfamily. It is classified as is a type III membrane protein with an extracellular N‑terminus in the absence of a cleaved signal sequence. The extracellular region of TACI contains two cysteine rich domains. Within the TNFRSF, it shares the highest homology with BCMA. TACI and BCMA have both been shown to bind APRIL and BAFF, members of the TNF ligand superfamily. TACI is expressed on the cell surface of B cells and activated, but not resting, T cells. Analogous to BCMA, data suggests that TACI may play an important role in B cell development, function and regulation. Human TACI is a 293 amino acid (aa) protein consisting of a 166 aa extracellular domain, a 20 aa transmembrane domain, and a 107 aa intracellular domain. Human and mouse TACI share 54% amino acid identity.

Long Name
Transmembrane Activator and CAML Interactor/Tumor Necrosis Factor Receptor Superfamily Member 13B
Entrez Gene IDs
23495 (Human); 57916 (Mouse); 102126451 (Cynomolgus Monkey)
Alternate Names
CD267 antigen; CD267; CVID; CVID2; FLJ39942; MGC133214; TACI; TACIMGC39952; TNFRSF13B; TNFRSF14B; Transmembrane activator and CAML interactor; tumor necrosis factor receptor 13B; tumor necrosis factor receptor superfamily member 13B; tumor necrosis factor receptor superfamily, member 13B

Product Datasheets

Citations for Human TACI/TNFRSF13B PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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  1. Correlation of APRIL with production of inflammatory cytokines during acute malaria in the Brazilian Amazon
    Authors: RA Pinna, AC Dos Santos, DS Perce-da-S, LA da Silva, RNR da Silva, MR Alves, F Santos, J de Oliveir, JC Lima-Junio, DM Villa-Verd, PM De Luca, CE Carvalho-P, DM Banic
    Immun Inflamm Dis, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. Control of Viremia Enables Acquisition of Resting Memory B Cells with Age and Normalization of Activated B Cell Phenotypes in HIV-Infected Children.
    Authors: Muema D, Macharia G, Hassan A, Mwaringa S, Fegan G, Berkley J, Nduati E, Urban B
    J Immunol, 2015;195(3):1082-91.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity.
    Authors: Hoffmann F, Kuhn P, Laurent S, Hauck S, Berer K, Wendlinger S, Krumbholz M, Khademi M, Olsson T, Dreyling M, Pfister H, Alexander T, Hiepe F, Kumpfel T, Crawford H, Wekerle H, Hohlfeld R, Lichtenthaler S, Meinl E
    J Immunol, 2015;194(2):542-52.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease.
    Authors: Sarantopoulos S, Stevenson KE, Kim HT, Cutler CS, Bhuiya NS, Schowalter M, Ho VT, Alyea EP, Koreth J, Blazar BR, Soiffer RJ, Antin JH, Ritz J
    Blood, 2009;113(16):3865-74.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. BAFF and APRIL expression in B-cell chronic lymphocytic leukemia: correlation with biological and clinical features.
    Authors: Bojarska-Junak A, Hus I, Chocholska S, Wasik-Szczepanek E, Sieklucka M, Dmoszynska A, Rolinski J
    Leuk. Res., 2009;33(10):1319-27.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  6. Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment.
    Authors: Tai YT, Li XF, Breitkreutz I, Song W, Neri P, Catley L, Podar K, Hideshima T, Chauhan D, Raje N, Schlossman R, Richardson P, Munshi NC, Anderson KC
    Cancer Res., 2006;66(13):6675-82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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