Human Tyrosylprotein Sulfotransferase 2 (TPST2) is a 42 kDa (predicted) member of a sulfotransferase family. Two human tyrosylprotein sulfotransferases (TPSTs), TPST1 and TPST2 mediate tyrosine O-sulfation of more than 60 different proteins in the Golgi, transferring sulfate from 3'-phosphoadenosine 5'‑phosphosulfate to tyrosine residues contained in polypeptides with acidic motifs to form a tyrosine O-sulfate ester. TSPT1 and TSPT2 are widely expressed, they show similar tissue distribution and overlapping substrate specificity.