Human UNC13B Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB6188V Datasheet / COA / SDS

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FAB6188V-100UG

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Human UNC13B Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human UNC13B in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) UNC13A and rhUNC13C is observed.

Source

Monoclonal Mouse IgG2b Clone # 584102

Purification

Protein A or G purified

Immunogen

E. Coli-derived recombinant human UNC13B
Asp418-Ser1591
Accession # O14795

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: UNC13B

UNC13B is a 170 kDa member of the unc13 family. It is 1591 amino acids (aa) in length and contains three C2 domains, one MHD1 domain, one MHD2 domain, and one phorbol-ester/DAG-type zinc finger. Human UNC13B is 95% and 93% aa identical to mouse and rat UNC13B, respectively. UNC13B is expressed in brain and kidney cortical epithelial and mesangial cells. UNC13B plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). In addition, UNC13B may be involved in mediating some of the acute and chronic changes in mesangial cells produced by exposure to hyperglycemia

Long Name

UNC-13 Homolog B

Entrez Gene IDs

10497 (Human)

Alternate Names

hmunc13; homolog of rat Munc13 (diacylglycerol-binding); MGC133279; MGC133280; MUNC13; munc13-2; MUNC13B; protein unc-13 homolog B; unc-13 homolog B (C. elegans); UNC13B; Unc13h2; unc-13-like (C. elegans); UNC13Unc13h2