Human VGLUT1/SLC17A7 Alexa Fluor® 750-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: VGLUT1/SLC17A7

Vesicular glutamate transporter 1 (VGLUT1), also known as SLC17A7, is an integral membrane protein involved in glutamate uptake into synaptic vesicles. The vesicular glutamate transporter (VGLUT) mediates the accumulation of neurotransmitter (glutamate) into synaptic vesicles. It is expressed in pre-synaptic vesicles. VGLUT proteins appear to be differentially expressed in myelinated afferents located in specific axonal populations within the spinal cord. VGLUT proteins are among the most specific markers for the identification of glutamatergic neurons. It is an essential molecular component of glutamate synaptic transmission, and its de-regulation can result synaptic failure and excitotoxicity.

Product Datasheets

Related Research Areas

• Neuronal Markers
• Neurotransmitter Transporters
• Solute Carrier Family (SLC)