VGLUT1/SLC17A7 in Human Brain. VGLUT1/SLC17A7 was detected in immersion fixed paraffin-embedded sections of human brain (cortex) using Mouse Anti-Human VGLUT1/SLC17A7 Monoclonal Antibody (Catalog # MAB9054) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to synaptic vesicles. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Preparation and Storage
Reconstitute at 0.5 mg/mL in sterile PBS.
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Vesicular glutamate transporter 1
(VGLUT1), also known as SLC17A7, is an integral membrane protein involved in
glutamate uptake into synaptic vesicles. The vesicular glutamate transporter
(VGLUT) mediates the accumulation of neurotransmitter (glutamate) into synaptic
vesicles. It is expressed in pre-synaptic vesicles. VGLUT proteins appear to be
differentially expressed in myelinated afferents located in specific axonal
populations within the spinal cord. VGLUT proteins are among the most specific
markers for the identification of glutamatergic neurons. It is an essential
molecular component of glutamate synaptic transmission, and its de-regulation
can result synaptic failure and excitotoxicity.
Vesicular Glutamate Transporter 1
Entrez Gene IDs:
57030 (Human); 72961 (Mouse); 116638 (Rat)
BNPI; BNPIbrain-specific Na-dependent inorganic phosphate cotransporter; Brain-specific Na(+)-dependent inorganic phosphate cotransporter; member 7; SLC17A7; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter); Solute carrier family 17 member 7; VGLUT1; VGLUT1vesicular glutamate transporter 1
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