Human VHL Alexa Fluor® 594-conjugated Antibody

Catalog #: FAB114351T Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
FAB114351T-100UG

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Human VHL Alexa Fluor® 594-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human VHL in direct ELISA.

Source

Monoclonal Mouse IgG1 Clone # 1066409

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human VHL
Asn150-Asp213
Accession # P40337

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 594 (Excitation= 590 nm, Emission= 617 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: VHL

VHL (von Hippel-Lindau disease tumor suppressor) is the substrate recognition subunit for an E3 ligase activity that ubiquitinates proteins containing hydroxyproline residues. Targets of VHL include HIF1 alpha, beta 2 adrenergic receptor, ZHX2 and others. In VHL-box E3 Ubiquitin ligases, VHL is bound to a heterodimer complex composed of Elongin B (ELOB) and Elongin C (ELOC) through the "BC-box motif" found in many proteins in the VHL-box and SOCS-box protein families. ELOB/ELOC serves as an adapter between substrate recognition proteins and Cullin-2 (or Cullin-5) and RBX1 to form an active E3 ligase.

Long Name

Von Hippel-Lindau Tumor Suppressor

Entrez Gene IDs

7428 (Human); 22346 (Mouse)

Alternate Names

elongin binding protein; HRCA1; Protein G7; pVHL; RCA1; VHL; VHL1; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau syndrome; von Hippel-Lindau tumor suppressor