Human WIZ Alexa Fluor™ Plus 488‑conjugated Antibody

R&D Systems | Catalog # FAB11743AFP488

R&D Systems

Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry

Label

Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Monoclonal Mouse IgG Clone # 1110627
View all WIZ Primary Antibodies »

Product Specifications

Specificity

Detects a synthetic peptide specific for human WIZ around amino acid 1100 in Direct ELISA.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG

Applications for Human WIZ Alexa Fluor™ Plus 488‑conjugated Antibody

Application
Recommended Usage

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: WIZ

Widely interspaced zinc finger motifs (WIZ) is an epigenetic regulatory protein with a molecular weight of approximately 95 kDa. This protein plays a critical role in chromatin remodeling and transcriptional regulation by interacting with key epigenetic modifiers such as G9a/GLP and other chromatin-associated complexes. WIZ is ubiquitously expressed across various tissues and is essential for maintaining proper gene expression patterns during development and differentiation. It has been implicated in processes such as neuronal development, where it facilitates neuron-specific gene activation and repression, and in safeguarding chromatin architecture. Dysregulation of WIZ expression or function contributes to pathological conditions, including various neuropsychiatric disorders and cancer, where its role in epigenetic silencing can influence tumorigenesis and disease progression. Mutations in the WIZ gene are associated with cognitive impairments and developmental delay syndromes, suggesting its importance in neuroplasticity and brain development. As a key mediator of chromatin dynamics, WIZ serves as a promising target for research into epigenetic therapies and biomarkers of disease.

References

  1. Mozzetta C, Pontis J, Ait-Si-Ali S. Functional Crosstalk Between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2. Antioxid Redox Signal. 2015 Jun 1;22(16):1365-81. doi: 10.1089/ars.2014.6116. Epub 2014 Dec 19. PMID: 25365549; PMCID: PMC4432786.
  2. Justice M, Carico ZM, Stefan HC, Dowen JM. A WIZ/Cohesin/CTCF Complex Anchors DNA Loops to Define Gene Expression and Cell Identity. Cell Rep. 2020 Apr 14;31(2):107503. doi: 10.1016/j.celrep.2020.03.067. PMID: 32294452; PMCID: PMC7212317.
  3. Simon JM, Parker JS, Liu F, Rothbart SB, Ait-Si-Ali S, Strahl BD, Jin J, Davis IJ, Mosley AL, Pattenden SG. A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin. J Biol Chem. 2015 Oct 23;290(43):26088-102. doi: 10.1074/jbc.M115.654459. Epub 2015 Sep 3. PMID: 26338712; PMCID: PMC4646261.

Long Name

WIZ zinc finger

Alternate Names

ZNF803

Entrez Gene IDs

58525 (Human); 22404 (Mouse); 314598 (Rat)

Gene Symbol

WIZ

UniProt

O95785 (Mouse)

Additional WIZ Products

Product Documents for Human WIZ Alexa Fluor™ Plus 488‑conjugated Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human WIZ Alexa Fluor™ Plus 488‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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