Human Wnt-1 (NP_005421.1) VersaClone cDNA

Catalog # Availability Size / Price Qty
RDC3801
Human Wnt-1 (NP_005421.1) VersaClone cDNA
1 Image
Product Details
FAQs
Reviews

Human Wnt-1 (NP_005421.1) VersaClone cDNA Summary

Specifications

Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

Product Datasheets

You must select a language.

x

Background: Wnt-1

Wnt-1 is a secreted glycoprotein that binds members of the Frizzled family of seven transmembrane domain receptors. First identified as a proto-oncogene activated in mouse model of mammary tumors, Wnt-1 is known to exert a wide range of functions. Effects of Wnt-1 include control of cell proliferation, patterning, motility, and fate determination. The secretion of Wnt-1 plays an important role in embryonic development and carcinogenesis. Wnt-1 may also affect morphogenesis of the neural tube and in Central Nervous System (CNS) development.

The Wnts make up a large family of secreted proteins with roles in pattern formation, cell fate decision, axon guidance, and tumor formation. Wnt family members vary in length between 350 and 400 amino acids (aa), possess 22 to 24 conserved cysteines, are highly hydrophobic, and show 20 - 85% aa identity within the Wnt family. In general, there are three signaling pathways associated with Wnt-receptor interaction. The first is commonly called the canonical pathway and ultimately culminates in beta-Catenin accumulation and TCF/LEF-1-mediated gene transcription. The other two less well-defined non-canonical pathways include the Wnt/Ca2+ pathway and the planar cell polarity (PCP) pathway.

Long Name
Wingless-type MMTV Integration Site Family, Member 1
Entrez Gene IDs
7471 (Human); 22408 (Mouse)
Alternate Names
Int-1; INT1Proto-oncogene Int-1 homolog; proto-oncogene Wnt-1; wingless-type MMTV integration site family, member 1 (oncogene INT1); wingless-type MMTV integration site family, member 1; Wnt1; Wnt-1

FAQs

No product specific FAQs exist for this product, however you may

View all cDNA Clone FAQs

Reviews for Human Wnt-1 (NP_005421.1) VersaClone cDNA

There are currently no reviews for this product. Be the first to review Human Wnt-1 (NP_005421.1) VersaClone cDNA and earn rewards!

Have you used Human Wnt-1 (NP_005421.1) VersaClone cDNA?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review