Human lymphotactin (Lptn)/XCL1 (also named human SCM-1 alpha and ATAC) and its mouse homologue belong to the C or gamma subfamily of chemokines. The C chemokines lack two (the 1st and 3rd ) of the four invariant cysteine residues normally found in the CC and CXC chemokines and have an extended carboxy terminus. Human lymphotactin encodes a 114 amino acid residue precursor protein with a 21 amino acid residue predicted signal peptide. The expression of lymphotactin is abundant in some activated T cells such as activated CD8+ T cells and other class I MHC restricted T cells. Lptn expression is absent in CD4+ T cells. Human and mouse Lptn share approximately 60% amino acid sequence homology. The gene for lymphotactin has been mapped to chromosome 1 in both human and mouse. Recombinant human lymphotactin has been shown to have chemotactic activity for lymphocytes and NK cells. The orphan receptor GPR5 has been reported to be the specific receptor for Lptn.
Human XCL1/Lymphotactin Alexa Fluor™ Plus 488‑conjugated Antibody
R&D Systems | Catalog # AF695AFP488
Key Product Details
Species Reactivity
Applications
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Antibody Source
Product Specifications
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Applications for Human XCL1/Lymphotactin Alexa Fluor™ Plus 488‑conjugated Antibody
Western Blot
Neutralization
Formulation, Preparation, and Storage
Formulation
Shipping
Stability & Storage
Background: XCL1/Lymphotactin
References
- Kennedy, J. et al. (1995) J. Immunol. 155:203.
- Zlotnik, A. et al. (1999) Critical Reviews in Immunol. 19:1.
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Additional XCL1/Lymphotactin Products
Product Documents for Human XCL1/Lymphotactin Alexa Fluor™ Plus 488‑conjugated Antibody
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Product Specific Notices for Human XCL1/Lymphotactin Alexa Fluor™ Plus 488‑conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
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Protocols
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