IFN-alpha/beta R2 Antibody (RM0251-5L16) - Azide and BSA Free

Novus Biologicals | Catalog # NBP2-11743

Novus Biologicals
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Key Product Details

Species Reactivity

Mouse

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2 Clone # RM0251-5L16

Format

Azide and BSA Free
View all IFN-alpha/beta R2 Primary Antibodies »

Product Specifications

Immunogen

Mouse recombinant IFN-alpha/beta R2 (extracellular domain)

Clonality

Monoclonal

Host

Rat

Isotype

IgG2

Scientific Data Images for IFN-alpha/beta R2 Antibody (RM0251-5L16) - Azide and BSA Free

Immunohistochemistry-Paraffin: IFN-alpha/beta R2 Antibody (RM0251-5L16) - Azide and BSA Free [NBP2-11743]

Immunohistochemistry-Paraffin: IFN-alpha/beta R2 Antibody (RM0251-5L16) - Azide and BSA Free [NBP2-11743]

Immunohistochemistry-Paraffin: IFN-alpha/beta R2 Antibody (RM0251-5L16) [NBP2-11743] - The Kidney tissue samples from the Folic Acid induced kidney injury model were fixed using 4% PFA at 4C for overnight and embeded in paraffin. 4um section was sublected to IHC with NBP2-11743

Applications for IFN-alpha/beta R2 Antibody (RM0251-5L16) - Azide and BSA Free

Application
Recommended Usage

Western Blot

1:50-1:200

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Reconstitution

Reconstitute with sterilized PBS to a final concentration of 0.5 mg/ml.

Formulation

Lyophilized from a 0.2 um filtered solution in PBS. 0.025 mg size is provided in liquid form, PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IFN-alpha/beta R2

IFNAR2, also known as Interferon alpha/beta receptor 2, has 3 isoforms, an isoform 1 that is 515 amino acid and 58 kDa, an isoform 2 that is 331 amino acid and 37 kDa, and an isoform3 that is 239 amino acid and 27 kDa; expressed in blood cells, lymphoblastoid and fibrosarcoma cell lines, isoform 3 is detected in the urine; is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta, stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Current research is being performed on several diseases and disorders including interferon, hepatitis c, hepatitis b, multiple sclerosis, measles, hepatocellular carcinoma, liver disease, breast cancer, myeloma, carcinoma, melanoma, adenocarcinoma, respiratory syncytial virus bronchiolitis, portal vein thrombosis, dengue hemorrhagic fever, cervical intraepithelial neoplasia, renal cell carcinoma, hemorrhagic fever, hepatitis c, and japanese encephalitis. This protein has been shown to interact with over 50 proteins including USP18, STAT2, GNB2L1, JAK1, and IFNA13 in cytokine-cytokine receptor interaction, osteoclast differentiation, toll-like receptor signaling pathway, Jak-STAT signaling pathway, natural killer cell mediated cytotoxicity, hepatitis C, measles, THC differentiation pathway, regulation of IFNA signaling and influenza A pathways.

Long Name

Interferon alpha/beta Receptor 2

Alternate Names

IFN-aR2, IFN-bR2, IFNAR2, IFNbR2

Gene Symbol

IFNAR2

UniProt

Q9D1R7

Additional IFN-alpha/beta R2 Products

Product Documents for IFN-alpha/beta R2 Antibody (RM0251-5L16) - Azide and BSA Free

Certificate of Analysis

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Product Specific Notices for IFN-alpha/beta R2 Antibody (RM0251-5L16) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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Associated Pathways

Jak/STAT Signaling Pathway Jak/STAT Signaling Pathway Thumbnail